I wonder if BioWare has considered entering the sex simulator market? They'd make a killing on pornographic games for all demographics!
I can imagine it now, Mass Effect 5: SSV Harem, where you are the commander of a crew representing an equally distributed spectrum of all races and genders and species. Even a Jokerette for those that prefer a very fragile female. And the Collectors are only aft... I'll stop.
But this sort of thing isn't the focus of the game, and if they sacrifice the depth of the story to individually model the beads of sweat clinging to the hairs on all the LIs, then the game would be lesser for it.
I'd buy it, and try out all the options of course. To deny my nature would be a disservice to myself.
However, not everyone in the world is gay, or even bi. And even if shep is, not everyone he meets will be someone he loves, no matter how much effort you may put into it. The relationships he can develop are real ones, the till death do us part kind. The contract expires there, though. No re-death, I don't think.
But in any case, enjoy the creative product that BioWare has labored to produce and hope feverishly that Jacob can be the main character in the next one (They say you can die in this one, how shocking!). He's really sensitive, if you catch my drift.