Of course they should do Dragon Age 4. What are you thinking? And then 5.
But ME should maybe be replaced by a new SF franchise.
Regarding the mix of Fantasy and SF. A thing that would be interesting is an Ian Banks style multi-galaxy SF universe that contains large, for practical purposes infinite, amounts of civilizations at varying levels of sophistication, size and power. Most of them, even the very old and very advanced, oblivious of the ancient, giant ultra civilization - which in its youth won every mega-annihilation-war anyone was ever foolish enough to start against them, still marked by those events, since most of its sentience is immortal, that is utterly omnipotent, but struggles to balance that with omniscient - which has a finger or two into everything but keeps itself invisible most of the time (like Bank's 'Culture').
You could do anything in a such universe. You could have a medieval level civilization, that nevertheless is exposed to advanced technology through interference with space travelling civilizations. You could have old, intricate cultures where technology has reached levels which equate it with magic. You could have Frank Herbert's 'Dune'. You could have Gene Wolfe's 'Book of the New Sun'.
Finally, the ancient ultra civilization is in effect the presence of a real God. A mostly passive, silent God, sometimes clumsy God, but ultimately always an omnipotent God. The role playing protagonists could in the epic end of every cataclysmic adventure, instead of dying, having proven their worth, be taken in, be made immortal and recruited by the ancient ultra civilization, i.e. go to heaven.