I'm sorry to say I finished this playthrough without further write-ups. There are several reasons for that. First, I didn't really find who I wanted Rune Cadash to be, so roleplaying was a bit of a mess, and as a result the way I experienced the different parts of the story was all over the place. Also, I had seen almost everything before, so if not for differences from the roleplaying viewpoint, there wasn't much I wouldn't repeat. And lastly, I played this game completely on "hard", and that meant I had to pay attention to the combat and couldn't get into the mindset for writing in-between.
However, there were significant differences I'd like to comment on now as I've finished this playthrough, as well as some more random observations.
(1) I played the templar storyline in this playthrough. Unfortunately, the envy demon and what it showed me didn't work at all for me and left me completely cold, as opposed to Alexius and the vision of a dark future in "In Hushed Whispers". I don't know exactly why, but the fact that my power fantasies tend to run more along Corypheus' lines may have been the main factor. Gaining a level of individual autonomy akin to a deity's, I'd easily be tempted by that. Meanwhile, more mundane power means you're always bound by the very organization you lead, as the Inquisitor herself amply demonstrates. While both kinds of power are desirable, there lies little temptation for me in the latter, and roleplaying characters who are different from me in that is particularly difficult.
(2) On the other hand, Calpurnia (spelled that way on purpose since IMO the game misspells the name) is a much more interesting antagonist than Samson, and the visit to Dumat's Shrine is much more enlightening about Corypheus in the "templars as allies" version. Samson always came across as not quite rational and somewhat stupid, while Calpurnia I could understand.
(3) All in all, I expected more parts of the game be more different between the mage and templar storylines. The only maps affected were the Shrine of Dumat and the final chamber in the Temple of Mythal. Particularly, it was disappointing that I still got red templars instead of Venatori on the rest of the Arbor Wilds map, and that the Emprise du Lion didn't change at all.
(4) I played this game on the "hard" setting, and as a result I paid more attention to equipment and crafting, doing things like visiting the Hissing Wastes early to get the materials for better equipment, and killing dragons specifically for the purpose of getting the bone, the scales and the webbing. I should say that all this was surprisingly enjoyable as I delved deeper into the mechanics of the combat, selecting talents for synergy, and as a result the fights became significantly easier over time, with some notable exceptions.
I have now played the game on three difficulty settings (normal, casual and hard), and I recommend trying the game on "hard" to anyone who's thought about it. The hardest encounter by far is the pride demon at the end of the prologue. It's a pretty good gating encounter: if you can beat that (it took me three attempts - none of the subsequent fights did that), you can also beat the rest of the game, and if you're well-equipped, you'll trash Corypheus in fairly short order. The only really annoying enemies are high-level melee rogues. If you don't pay close attention to them and they get lucky with their criticals, one of them can kill your party before you've even noticed you're dead. Also, the Revenants in the Cradle of Sulevin are "poof, you're dead" material, particularly in high levels. I got there at L23. It's not so much the Revenants alone that make this difficult, but they're accompanied by hordes of Corpse Archers.
I also killed all the dragons, and only needed my focus ability (which I find OP to the point of being almost a cheat, see below) in the two fights where I was underleveled (L18 against the L20 Hissing Wastes dragon and L21 against the Highland Ravager). Most notably I didn't need it against Corypheus.
(5) Rune Cadash was a ranged Rogue, and I found ranged Rogues are badass. I chose the Artificer specialization but mainly for the passives and the focus ability. Stealth isn't quite as good as Fade Step in order to get away from enemies that get too close, but works well enough alternating with Leaping Shot. Damage output doesn't come close to a melee Rogue's I guess, but it can be insane nonetheless. I once one-shot a Red Templar Behemoth.
(6) Story-wise, the impression that the main storyline is incomplete remains. Not so much because of the ending, which is a real ending, but the pacing appears to be off and I continue to think that there should be another main plot mission between Here Lies the Abyss/Wicked Eyes and Wicked Hearts and What Pride has Wrought. Or somewhere else, depending on how you play. Also, how the Breach is handled is confusing: you close it early mid-game, but still people refer to a hole in the sky for the rest of the story. Why is that? I suspect some serious restructuring has happened at some time rather late in development. Also, the lack of a city hub deserving of the name becomes ever more noticeable.
(7) I very much dislike the distribution of the schematics, and the fact that I have to depend on random drops for anything outstanding. I find dozens of dagger schematics (I don't use melee rogues) and dozens of greatsword schematics (I don't use two-handed fighters) while bows and staffs are rare. I found exactly one tier 3 masterwork bow schematic by random chance and no masterwork staff schematic at all, and you can buy some tier weapons 3 schematics, but if you go by the standard map sequence, only at a point where one map is left to play with them. I also have no tier 3 headgear schematics at all.
(8) On the other hand, I love the design of the armors. Not that they're really realistic, being much too beautiful to be dirtied in real combat, but they do look functional with things like breastplates protecting the vitals even in the medium armors and believable padding in the light ones. Some of the gloves and boots are ridiculous, but overall it's a very good compromise between functionality and aesthetics. I think Bioware has hit the sweet spot in this. I can even forgive Sera since she's clearly made around the idea of not being where the sharp metal hits rather than deflecting attacks.
(9) I'm of two minds about the way the "faith and doubt" theme has been handled. I can't fault the roleplaying opportunities I get (except in one case, at that cult in the Hinterlands) and I'm mostly happy with them, but the story's reactivity to my choices in that regard leaves something to be desired. Basically, I can't make my stance actually affect anything, even in minor ways, in spite of the power I wield. Which may not be all that implausible, but it means that the Inquisitor may go down in recorded history as the leader of a organization whose power rests largely in faith, regardless of the fact that my Inquisitors tend to go out of their way to tell people that they should have faith in what they can do rather than in distant gods. Well, I guess nobody gets a say about how history treats them, but as players we are in the unique situation of being able to read future accounts in the next games.
(10) I have now played the game with characters of three difference races: human, elf and dwarf. They feel sufficiently different to be worth replaying the game IMO, but the dwarf feels a little disconnected. The elf feels naturally part of the story, mainly because of what happens in the final chapter, and my human mage feels naturally part of it because she's a mage. I also have the occasional race-specific option or reaction. This aspect might be a little underdeveloped still, though I commend Bioware of making the game react to the choice at all in more than cosmetic ways.
(11) This was my most "completionist" game so far. I have found all but three mosaic pieces, all regions but the bugged one, all bottles, landmarks, shards etc.. and I'm only missing once piece of the Notes on the Wastes (is there a dungeon that opens if you have all of them? If so, I'm missing that, too of course). However, I'm missing a ton of Codex entries - I estimate about 20% in the history and tales sections. That's immensely galling. I will attempt to rectify that on my replay of my first Inquisitor, which will come next, albeit much more slowly than before.
And finally, here some screenshots of my last playthrough:
Rune Cadash entering Adamant Fortress:

Rune Cadash in Val Royeaux. The armor is dragonscale sturdy prowler armor and the Cowl of the Overseer

Rune Cadash's endgame team. All in crafted armors and weapons.
