I'd like to start by saying that I think a lot of people on here haven't properly read / understood the System Requirements.
I would also like to say that when the System requirements came out, I immediately presumed I would need to buy a new CPU for my PC, and probably a new Video Card.
I am glad to say I was wrong.
I have an Intel i3-3240 CPU, which is technically only a Dual-Core CPU, not the Quad-Core stated in the System Requirements. Nevertheless, the game runs flawlessly. I have had no issues with CTD, Audio Stutter, Menu freezing, or any of the other problems people have been complaining about.
I did have a slow experience in cutscenes and conversations, but after using the benchmark tool, I found a maximum FPS on my system of 5.6 FPS. Yep, that's only 5 frames per second. So I upgraded my video card from an ASUS Nvidia GeForce GT610 to a Gigabyte Nvidia GeForce GTX 750ti, and ran the benchmark tool again. I was on 54 FPS. And that's all using the "Low" graphics setting...
I've played now a total of about 35 hours of this game - the first 30 were with my old card, and a 5 FPS system.
So this game is NOT unplayable. It DOES have poor PC controls, and there are some design choices I just do not comprehend (like the looting system / radius, and the inventory management / crafting system not speaking to each other) but those are personal preferences, not game breaking issues.
For anyone who'd like to question my gaming history, here's a brief synopsis: I have been playing PC games since I built my first rig in 1990, on an 086 CPU base. I've played mainly RPG's, everything from Zork to Wizardry to Quest For Glory to BG and now Mass Effect and Dragon Age. The first MMO I played was The Old Republic, followed by Elder Scrolls Online. Furthermore, I don't own a console, so all of my gaming is on PC, and PC only.
The point I'm trying to make here, and I'll admit it's taking a while, is that the issues people are complaining about are either cosmetic, or because their system has issues.
But the way I judge an RPG is to ask the question "Could I pretend I was someone else living in a different world, where I cared about the things that happened?" And to that question, I think the answer is a resounding yes. The NPC interactions and conversations are engaging and realistic. The world (with the exception of spawning times) is quite realistic, and is amazingly visually detailed. The story in and of itself is great, easy to go through, and rewarding for everything you do.
So, basically, I love the game. I hate some of the implementation design choices, such as having a compass, not a minimap, and having it in the bottom left rather than the top right (or left, but I'm a rightie so right is more natural for me). I also hate the way the crafting system needs you to have memorised the stats of your character's gear, because it won't offer a comparison to what you're currently wearing. I REALLY hate that there's a functionality in Multiplayer that's missing in Single-player - Item salvaging.
But these hates are small frustrations in light of the massive open world of content that we have to explore in this game.
So calm down people. Check your system specs. Check your Anti-virus software. If you don't have AV software, get some, then check it. Make sure you're running a 64-bit OS, and not a 32-bit OS on a 64-bit system. Check your drivers. Disable any in-game overlays, and learn to be patient with your system.