I'm only about 25 hours in and on a lower-end PC so I don't know if the problems I've seen only affect me, but so far:
Envy demon fight: First cutscene the entire party stands like a scarecrow, Cole (not yet in party) as well but his face moves. After cutscene ends Envy Demon shows up and moves around as normal but my party remains frozen, so I have no idea what they're doing. "Fixed" by having my inquisitor hug the right wall until she got to around the middle of the field and the cutscene triggered normally. Then got a strange issue where Envy Demon would get down to very little health, then my screen would go black. I would hear sounds of fighting and then I would see "Your journey ends...". This was "fixed" by moving my Difficulty down to Casual and keeping my left mouse button held down; my inquisitor then made short work of the demon and I got my visuals back once it was dead.
The keep in Crestwood (Caer Bronach) -- ran away from a fight at the top of the keep with two doors I couldn't open nearby (one says "You must take the keep first" while the other says "You can only open this door from the other side", paraphrased); when I came back, the enemies were gone save for a single outlaw I couldn't fight. He kinda just stood there and moved out of the way if I ran into him. This makes it impossible to take the keep and thus progress in Crestwood's main quest as I can't open any doors or gates in the keep without having taken it first--what does that mean if there's no enemies left?