I am on a 360 and consistently have the cut scene glitch at Adamant (2 play throughs). Dialogue just...stops, no amount of "x"ing make it start up again. Have to reload to get it to let you "x" through (it never just works). This one is consistently specific for me.
I also do not like the fact that you cannot install the second disk. I have three copies of ME 3 where the second disk gets that split from the spindle into the data (before I discovered that you can install the game on the hard drive). Thank god you can buy used copies of the game for cheap.
Dialogue doesn't progress at other spots either but you can "x" through.
Characters drop out of the sky
Landscapes pop in out of the blue.
Dialogue wheel doesn't show later on in the game (wonder if there's so much data it has trouble loading)
Dialogue gets scrambled.
Sound pops in and out, comes and goes all through the game.
Game freezes more often later in the game.
Game freezes attempting to bring up quest map.
Quest "Playing with Fire" is bugged. Couldn't get close enough to the base of the statue because of the inquisitor banner to go around three times and get it to continue.
Game freezes at door transitions.
I have instituted a new exercise program where I get up and run in place while the screen loads. I have a feeling this could be a real calorie burner for me.