I was really nervous about speaking to Krem about his being trans at first because of the dialogue options.
I was super scared of offending him, but he was a sweetheart about all my questions.
You know I was like that at first but then I decided it just wouldn't fit my Inquisitor to go all eggshells around him. My Lady Adaar is used to people looking at her weird and treating her like a freak on account of her horns, she would rather people just get over it and treat her like a person. So she rarely gives a crap about offending others with a lot of her actions and words. That doesn't mean she's disrespectful, but she has no problem speaking her mind, no matter who it offends.
Therefore the idea of having her suddenly not be that forthcoming when talking to Krem, just because he's trans, simply didn't work for me. It was treating him differently just because of his gender identity. To say the least, this was both inappropriate and counterproductive.
Instead my Inquisitor fearlessly strolled right up and bluntly asked what she wanted to ask. I had no problem with her bumbling and potentially insensitive questions because the fact is most people are like that. Many people don't really understand what it means to be transgendered - even for simple things like why they may be using the wrong pronouns - because most people don't have the opportunity to learn. And it's only by messing up and asking stupid questions that people can gain understanding and get past the awkwardness.
So I fully enjoyed the chance to cheerfully, and bluntly, ask all those potentially embarrassing questions, as well as get the wonderful 'well duh!' answers. I especially loved Bull's responses, I don't think I truly understood Krem until I saw him through Bull's perspective.
That said I did wait until I could talk to Krem and Bull separately about it. In part out of respect, but also because there was no reason to bring it up when meeting the rest of the Chargers. It would have been unfair for Krem's gender to overshadow the rest of the awesome characters in the Chargers. It's just a part of his character, not his entire character, and there's no reason it should be more important then discussing Dalish and her use of "Archery" ( not magic ) with her special "Bow" ( not a staff ).
Did I mention how badly I want a Bull's Chargers DLC?