Just to throw my info into the ring:
AMD Athlon 64 Processor 3500+
Clock: 2219 MHz
RAM: 2 GB
Vid: NVIDIA GeForce 9800 GT, drv 196.21, VRAM 512 MB
Microsoft Windows XP Home Edition
DirectX 9.0c
Same hang on loading. Some initial stuttering on the Bioware opening splash.
BTW, when I played DAO, about 5-6 cut scenes stuttered throughout the whole game for me. I could hit esc, and it would bypass the rest of that scene and go to the next one (or back to the game).
On another note-- In looking at Task Manager while it's hung, I notice CPU utilization is down in the 5-8% range (fluctuations... normal background processing). PF usage was up at 1GB. In my experience, when hung processes have been related to **inadequate** CPU, the utilization will be pegged (100%) while it's not responding. It will often take a while (20-30 seconds) for Windows to even respond to Ctrl-Alt-Del (as expected). On about 2 out of 3 hangs for ME2, I can get into Task Manager immediately. On the 1/3 times, I'm totally hosed... requires a cold boot.
BIOWARE DEVS: In case anyone in BIOWAREland happens across this post--- I just userdump'd my hung MassEffect2.exe process. It's almost a 1 GB file. If you're interested in the dump file, you'll need to PM me and provide an FTP site (or other means to get it to ya). (Verfied Bioware accounts only please.)