This is my understanding. Take a warrior, as a for instance. Regardless of one handed or two handed, you should spam strength onto your weapon wherever possible. This is how you increase damage. I'm not sure how much effect attack has, if it's available, but I know that your final damage done comes from strength. By the same token, you should spam constitution onto your armor and if that's not available put health on it.
Early in the game you can use the anti-armor bonus, but late in the game you want to add as much anti-guard as possible. That's so you don't have to kill the same opponent 3 or 4 times.
When taking perks, you need to make either warrior type balanced for strength and constitution in order survive long enough to use your mighty weapon to dispatch the miscreant. At least that's what I do.
Edit: Went by the linked topic and it makes good sense. Might slightly change the way I make armor and weapons, but maybe not. lol.