Cassandra was fairly on the mark: we didn't see her in-depth in II, but her character's easily recognizable. Bit of a hardass towards prisoners and during interrogation, ultimately good intentions, and something of a romantic nature (only vaguely touched upon in II, but there). Of course, I haven't seen Dawn of the Seeker. Varric, definitely different, but he's out of his element and his development makes a fair amount of sense.
Cullen's definitely changed from his Origins direction. That's not to say his current development doesn't make sense, but it seems different from where he was going back then. The creepy epilogue, the gradual slide. Whether or not I prefer this development isn't quite the same as if I think it's changed, I'll note; I'm fairly neutral, bit annoyed most of his development ended up taking place off-screen.
Having read Asunder, Cole felt very different. Cole was never the beacon of normalcy, and was ultimately good-intentioned, but he spoke much like a normal human was and didn't have a big thing about helping people (he mercy killed people because seeing their eyes as he snuffed out their lives made him feel important and "real"). Still creepy, and sympathetic (my description probably doesn't do him justice), but a different type of creepy. This can be explained by him becoming more in touch with his spirit nature, but it's still kind of weird.
It seems like cheating to count Hawke -- player character and all -- but their character stood in contrast to some given options in II so I'll count it. It was possible to play a Hawke who annulled the Circle not to kill blood mages (as Inquisition Hawke states), but to limit casualties from a choice taken out of their hands. And, of course, you could friend Merrill and see the benefit in her blood magic. Oh, and actually sell someone's soul to a sloth demon, seems a bit weird to criticise blood magic after doing that.
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