I have a sneaking suspicion that this film is going to do a number of things wrong, and make it a highly unenjoyable film.
1. Make it too comedy-centric. Ghostbusters 1 was a film that had a lot of funny dialogue and good chemistry between the cast, but when scary and tense **** was happening, they knew how to focus on that, even when putting in funny lines of dialogue to counter-balance the creepy ****. It knew how to be both funny, and creepy, when it needed to. Second film not so much, with its statue of liberty saving the day and really dumb evil mood slime. Like, they tried to make it too funny, and by doing so, took away from the other elements, the tense or creepy elements or just plain good writing the previous film had, by over-doing the comedy. I fear this film will do the same, not allowing drama or tension to form and making the film less interesting to watch.
2. "Modern Comedy Techniques" IE a reliance on awkward shock comedy and repetition to get a laugh out of people, over actually good banter and fast deliver. For example, iin Ghostbuster movie character gets slimed, they get up and deliver a really funny line and we move on. In the new film, character 1 gets slimed. Have an extended sequence of the characters being grossed out by the slime, then character one taste some of the slime, proceeds to throw up, another extended sequence of stating how gross it is, than one of the characters cracks a joke about this not being the grossest thing they'd been through. Awkward silence and hold on shot, before we jump cut to the slimer ghost.
3. An over-abundance of jokes about the old films, be it callbacks to the previous films that the new cast can mock, or references to stuff followed by the cast saying how dumb or stupid that is. These tend to be common in a lot of new sequels, especially with a lot of time between installments. And they are torture, mostly cause you can see the punchline coming, and rarely are they actually funny.
4. Politics. Plain and simple making this film more concerned with social commentary with a political bias then telling an actually funny story. This can be achieved a number of ways, such as having an antagonist character reference a real life political figure or political party, especially ad naseum, in reference to the motivation of their actions. Or having a specific reference to some current event issue with some opinion on it, be it the current federal administration, foreign affairs, local issues, what have you. But it always, always, is out of place and distracting unless the film is specifically made to address political issues. The fact that they made an all female cast, and felt the urge to parade it around like some sort of side-show attraction to get gold stars and praise, and had to do the same for the "guy-centric" ghost corps crap idea, rather than treating this decision like any other casting release, is troubling.