150 réponses à ce sujet

[God]

 

Wiki reference:
Eezo exposure is by no means guaranteed to result in biotic ability. On the contrary, most fetuses that are exposed are not affected at all. Others will develop brain tumors or other horrific physical complications. In humans, only about one in ten eezo-exposed infants will develop biotic talents strong and stable enough to merit training, and these abilities are not always permanent. In extremely rare cases, humans who were exposed in utero but did not manifest biotic talents as children can develop them during young adulthood through additional exposure.

 

Ok. So you're confirming my point. All of this is confirmed by... element zero in the bloodstream! As well, this also deals with how a previously non-biotic mother is having a fetus develop after exposure. It's not quite the same as a second-generation trait that may be inherited. 

There are other similar references in the trilogy. Sorry, but I have better things to do than search for them.

 

 

Ok. Then you also acknowledge that you concede this point.

No, actually, I don't. That they did it at all is enough for me. A huge waste of a lot of talent.

 

 

I agree, though I blame the people themselves for no longer maintaining their own utility. They knew what would happen if they fled. They were aware of the risks. 

 

That said, I wonder if we even need people at all if we could create a fully functional advanced intelligence. Something like an AI in Halo. We could potentially use the AI as our laboratory test bed.

[sH0tgUn jUliA]

I've missed these discussions.

 

I think Cerberus had bad PR. That's one area The Illusive Man really lacked, especially after the reapers invaded. Well, it's mostly Mac's fault. They just needed another mook for us to kill because otherwise we'd be complaining of shooting at only one kind of monster. "Reapers" were basically the mooks from the different races. Cerberus were the mooks from an organization.

 

Give that the Reapers were also an enemy of Cerberus, one would have thought The Illusive Man, instead of fighting the Alliance and the others for the same resources would have sent Kai Lame to The Citadel in the beginning with one of those hand held things....

 

"I'm not here to fight you, but to propose an alliance. While your empires were squandering time, I've spent the past 20 years studying the Reapers and their technology in addition to getting my hands on every single Prothean artifact I could find. I've built a military based upon the technology of the Reapers and Protheans that rivals that of the Turians. I know more about the Reapers than all of your scientists put together. I don't know about you, but I'm ready to kick some ass. I can't do it alone. None of us can. I understand each of you thinks you have your little worlds to protect, but if we don't stand together you might as well put guns up to your heads and end it now because everyone will die. So I'll make you this one time offer. Join me or stay out of my way. Those who stand with me will reap the spoils of this war. Those who do not will be left behind and forgotten."

[Pasquale1234]

Ok. So you're confirming my point. All of this is confirmed by... element zero in the bloodstream! As well, this also deals with how a previously non-biotic mother is having a fetus develop after exposure. It's not quite the same as a second-generation trait that may be inherited.

No, not exactly. You were suggesting:
1) That Jack became a more powerful biotic than she would have been sans Cerberus' interference, and
2) That she would have more powerful biotic children as a result

We still don't know whether or how biotics will be passed from parent to child - but if it works the same way as other types of in-utero eezo exposure, "only about one in ten eezo-exposed infants will develop biotic talents strong and stable enough to merit training, and these abilities are not always permanent." It's also possible that human biotics may have or develop genetic mutations that would pass biotic ability to their children. We don't know much about that yet.

It says nothing about any relationship between the strength of the parents' biotics and that of any potentially biotic children - which is what you initially posited.

But it's an entirely tangiental discussion.
 

Ok. Then you also acknowledge that you concede this point.

Again - not exactly.

You keep adding absolutes in various forms to a statement I made awhile back, and then trying to get me to prove it. 'Always' and 'never' are generally unprovable. If you need more evidence regarding Cerberus' treatment of contractees who complete their assigned project and/or attempt to leave their employ, I suggest you seek it out.

[Pasquale1234]

I've missed these discussions.

I think Cerberus had bad PR. That's one area The Illusive Man really lacked, especially after the reapers invaded. Well, it's mostly Mac's fault. They just needed another mook for us to kill because otherwise we'd be complaining of shooting at only one kind of monster. "Reapers" were basically the mooks from the different races. Cerberus were the mooks from an organization.

Give that the Reapers were also an enemy of Cerberus, one would have thought The Illusive Man, instead of fighting the Alliance and the others for the same resources would have sent Kai Lame to The Citadel in the beginning with one of those hand held things....

"I'm not here to fight you, but to propose an alliance. While your empires were squandering time, I've spent the past 20 years studying the Reapers and their technology in addition to getting my hands on every single Prothean artifact I could find. I've built a military based upon the technology of the Reapers and Protheans that rivals that of the Turians. I know more about the Reapers than all of your scientists put together. I don't know about you, but I'm ready to kick some ass. I can't do it alone. None of us can. I understand each of you thinks you have your little worlds to protect, but if we don't stand together you might as well put guns up to your heads and end it now because everyone will die. So I'll make you this one time offer. Join me or stay out of my way. Those who stand with me will reap the spoils of this war. Those who do not will be left behind and forgotten."

TIM & Cerberus were frequently at odds with not only the Alliance and Council, but pretty much the rest of the galaxy. He didn't want to defeat the reapers, but to control their power and technology. For any single entity to wield that much power would never be acceptable to the other species, so it was a no-go from the get-go.

It's possible, I suppose, that he could have strung them along and used them as resources in his other activities instead of fighting them every step of the way - but it is doubtful that any of them would have trusted him enough to follow his lead. Attempting to ally with major powers would also require him to reveal himself to them - and he seemed to prefer the shadows.

[Esthlos]

Just chiming in to point out that usually exposing embryos (fetuses are a little more resistant, but it's still dangerous) to mutagenic factors such as EEZO is stated to be usually doesn't combine well with their survival and health, and it is thus highly probable that a powerful human biotic such as Jack will be unable to ever have healthy and living children of her own... that is, in case she isn't straight up sterile, given that eggs whose DNA mutated too much cannot properly mature, merge, and create embryos.

I reckon though that DNA seems to be a much more abstract concept in the Mass Effect universe as even items and machines seem to be able to be given one (BSynthesis ending), which effectively throws much of Biology as we know it out of the window...

[aoibhealfae]

it took me three ME3 playthrough or so.. for me to ignore the need for Journal. Luckily, I'm on PC... you can just wikia everything

[aoibhealfae]

Just chiming in to point out that usually exposing embryos (fetuses are a little more resistant, but it's still dangerous) to mutagenic factors such as EEZO is stated to be usually doesn't combine well with their survival and health, and it is thus highly probable that a powerful human biotic such as Jack will be unable to ever have healthy and living children of her own... that is, in case she isn't straight up sterile, given that eggs whose DNA mutated too much cannot properly mature, merge, and create embryos.

I reckon though that DNA seems to be a much more abstract concept in the Mass Effect universe as even items and machines seem to be able to be given one (BSynthesis ending), which effectively throws much of Biology as we know it out of the window...

 

Not really. Jack and most human biotics aren't likely to be sterile just because their enhanced abilities. Genetic mutation are essential to evolution. biotic manifestation among human is one of them. And it doesn't add extra chromosomes or anything.. think of it like x-men science.

Which is why the Reapers (Harbinger) think human as the ultimate potential for their research (like their fifty thousand years old experimentation on the Protheans and creating hybrids of synthetic and organic beings... they're really pushing for Synthesis future even without the Crucible.. )

 

and this isn't like Miranda who herself are an amalgam of her father's genetic materials and genetic modification from various sources and although she's intended to be perfect but genetically she's flawed and more synthetic and man-made than Shepard's reconstruction. Which is why she's sterile.

[Iakus]

So very true. The best abuse of  biology of ME for me was the Thorian.  A plant like being can clone a fully grown and complex organic being wearing full body armour

Well, to be fair, teh armor was probably so the game didn't get stuck with an AO rating

[Esthlos]

Not really. Jack and most human biotics aren't likely to be sterile just because their enhanced abilities. Genetic mutation are essential to evolution. biotic manifestation among human is one of them. And it doesn't add extra chromosomes or anything.. think of it like x-men science.

Which is why the Reapers (Harbinger) think human as the ultimate potential for their research (like their fifty thousand years old experimentation on the Protheans and creating hybrids of synthetic and organic beings... they're really pushing for Synthesis future even without the Crucible.. )
 
and this isn't like Miranda who herself are an amalgam of her father's genetic materials and genetic modification from various sources and although she's intended to be perfect but genetically she's flawed and more synthetic and man-made than Shepard's reconstruction. Which is why she's sterile.

I don't want to sound rude, but you seem to have a rather cartoonish understanding of basic Biology.

First of all, evolution doesn't work like that; ever heard the expression "survival of the fittest"?
Well, that's all evolution's about.
Let's say two mutations occur: one allows you to alter the fabric of space and time, the other makes you hornier.
Unless space and time are torn asunder (or something equally apocalyptic happens), evolution will favour the trait "being hornier" and discard the trait "being able to bend the space-time continuum at will".
That's because being hornier you will be prone to having more children, which is the propulsive force of evolution: having the most children.

Even the smallest mutation can be deadly: for example, some tumors are due to a single aminoacid being mutated in the genetic code of a single protein in a single cell.
Mutations are random: evolution merely selects those that happen to improve the chance of surviving until you are able to have children. About anything else, or about whatever happens to you after you had children and helped them have children of their own, evolution simply doesn't care.

Secondly, man-made modifications are no different than natural modifications, and evolution treats them as equals. Thus, if we assume that actual Biology works in the Mass Effect universe too, then it is nonsense to state that Miranda is sterile bacause "she's partly synthetic", unless her sterility is due to the genes needed for having children having been removed from her DNA in order to give her "better" genes.
"Better" in this last sentence is used from a corporate point of view; for evolution, the best and most important genes are instead those related to fertility and survival, not to powers or skills.

[KaiserShep]

Secondly, man-made modifications are no different than natural modifications, and evolution treats them as equals.

 

That depends on the nature of the modification. The use of gene therapy to correct muscular or skeletal degeneration due to long exposure to low gravity would not be hereditary.

[Esthlos]

That depends on the nature of the modification. The use of gene therapy to correct muscular or skeletal degeneration due to long exposure to low gravity would not be hereditary.

Correct, but it doesn't matter since natural mutations too don't necessarily involve the genetic code of the gametes.

[God]

No, not exactly. You were suggesting:
1) That Jack became a more powerful biotic than she would have been sans Cerberus' interference, and
2) That she would have more powerful biotic children as a result

We still don't know whether or how biotics will be passed from parent to child - but if it works the same way as other types of in-utero eezo exposure, "only about one in ten eezo-exposed infants will develop biotic talents strong and stable enough to merit training, and these abilities are not always permanent." It's also possible that human biotics may have or develop genetic mutations that would pass biotic ability to their children. We don't know much about that yet.

It says nothing about any relationship between the strength of the parents' biotics and that of any potentially biotic children - which is what you initially posited.

But it's an entirely tangiental discussion.

 

1) The answer to this is yes, Jack did become a more powerful biotic due to Cerberus intervention than she would have normally.

 

2) I don't think the same issues concerning first exposure will be so prevalent. It's true, we have no real information on biotic offspring among humans, namely because the oldest human biotics themselves are only entering their late-30's. 

 

Going by other species, it looks as though biotics can be inherited. 
 

Again - not exactly.

You keep adding absolutes in various forms to a statement I made awhile back, and then trying to get me to prove it. 'Always' and 'never' are generally unprovable. If you need more evidence regarding Cerberus' treatment of contractees who complete their assigned project and/or attempt to leave their employ, I suggest you seek it out.

 

 

That's because you've added the absolutes to the argument on your own. 

 

You have said that Cerberus will always kill their employees when they complete a project. You have said they will always kill anyone who leaves their employ for any reason.

 

It's up to you to prove this to me that Cerberus treatment of a select group of deserters and traitors is the norm for all employees. It is not up to me to seek the evidence you lack.

[God]

Secondly, man-made modifications are no different than natural modifications, and evolution treats them as equals. Thus, if we assume that actual Biology works in the Mass Effect universe too, then it is nonsense to state that Miranda is sterile bacause "she's partly synthetic", unless her sterility is due to the genes needed for having children having been removed from her DNA in order to give her "better" genes.
"Better" in this last sentence is used from a corporate point of view; for evolution, the best and most important genes are instead those related to fertility and survival, not to powers or skills.

 

I think that's the general premise of a lot of Miranda fans, especially when analyzing the cause of her sterility. Miranda's actual physical cause of sterility is treatable by today's medicine and practices. 

 

That's also to say that this is Miranda. I'm sure she'd find a way to overcome her sterility if she set her mind to it. She did bring a man back from the dead after all.

[von uber]

With the help of a very well funded science team don't forget.

[God]

I'm not, but I'm saying that if she has the drive and ability to do that, then she should be able to come up with a medical reversal for her own sterility.

[Iakus]

Ooh!  Ooh!  ANother thing that makes no sense!  The Reaper Rannoch battle!

 

Orbital bombardments like that are considered a Tier I weapon of mass destruction.  Remember the "Sir Isaac newton is the deadliest SOB in space" lesson from ME2?  Having an entire fleet of ships firing down on a planet should have killed Shepard, the Reaper, anyone in the vicinity, and quite likely the planet.  At the very least, it would have experienced an ELE-style global winter.

[God]

Nah, ME1 weapons aren't that jacked up powerful. Especially with the significantly reduced yield. There's an explanation behind it that doesn't involve 'the writers fucked up'.

 

One ODP-grade SMAC in Halo outfires the entire Reaper armada with one shot. It would take them firing in perfect coordination 5.62 shots on the same area to equal the energy behind one SMAC round. And said SMAC can fire once every 5 seconds.

[Pasquale1234]

That's because you've added the absolutes to the argument on your own.

False.

[Vazgen]

Ooh!  Ooh!  ANother thing that makes no sense!  The Reaper Rannoch battle!

 

Orbital bombardments like that are considered a Tier I weapon of mass destruction.  Remember the "Sir Isaac newton is the deadliest SOB in space" lesson from ME2?  Having an entire fleet of ships firing down on a planet should have killed Shepard, the Reaper, anyone in the vicinity, and quite likely the planet.  At the very least, it would have experienced an ELE-style global winter.

Isn't that about asteroid strikes? It appears it is. Codex

TIER I: Large kinetic impacters, such as asteroid drops or de-orbited space stations. Effectively free and available in any system (in the form of debris left over from planetary accretion), kinetic impacters are the weapons of choice for terrorists and "third galaxy" nations.

[Iakus]

Asteroids are simply cheap and easy ways to get that effect.  But the mass drivers of warships has the same effect

 

 

Gunnery Chief: This, recruits, is a 20-kilo ferrous slug.  Feel the weight.  Every five seconds, the main gun of an Everest-class dreadnought accelerates one to 1.3 percent of light speed.  It impacts with the force of a 38-kilotomb bomb.  That is three times the yield of the city buster dropped on Hiroshima back on Earth.  That means Sir Isaac Newton is the deadliest son-of-a-****** in space.  Now!  Serviceman Burnside!  What is Newton's First Law?

First Recruit: Sir!  A object in motion stays in motion, sir!

Gunnery Chief: No credit for partial answers, maggot!

First Recruit: Sir!  Unless acted on by an outside force, sir!

Gunnery Chief: Damn straight!  I dare to assume you ignorant jackasses know that space is empty.  Once you fire this hunk of metal, it keeps going till it hits something.  That can be a ship, or the planet behind that ship.  It might go off into deep space and hit somebody else in ten thousand years.  If you pull the trigger on this, you're ruining someone's day, somewhere and sometime.  That is why you check your damn targets!  That is why you wait for the computer to give you a damn firing solution!  That is why, Serviceman Chung, we do not "eyeball it!"  This is a weapon of mass destruction.  You are not a cowboy shooting from the hip!

Second Recruit: Sir, yes sir!

 

 

Now imagine dozens, hundreds of warships firing down at one point on a planet

[von uber]

The thing is Iakus is that the gunnery chief doesn't have the complete specifications of shep's plot armour.
That changes the variables.

[aoibhealfae]

I don't want to sound rude, but you seem to have a rather cartoonish understanding of basic Biology.

First of all, evolution doesn't work like that; ever heard the expression "survival of the fittest"?
Well, that's all evolution's about.
Let's say two mutations occur: one allows you to alter the fabric of space and time, the other makes you hornier.
Unless space and time are torn asunder (or something equally apocalyptic happens), evolution will favour the trait "being hornier" and discard the trait "being able to bend the space-time continuum at will".
That's because being hornier you will be prone to having more children, which is the propulsive force of evolution: having the most children.

Even the smallest mutation can be deadly: for example, some tumors are due to a single aminoacid being mutated in the genetic code of a single protein in a single cell.
Mutations are random: evolution merely selects those that happen to improve the chance of surviving until you are able to have children. About anything else, or about whatever happens to you after you had children and helped them have children of their own, evolution simply doesn't care.

Secondly, man-made modifications are no different than natural modifications, and evolution treats them as equals. Thus, if we assume that actual Biology works in the Mass Effect universe too, then it is nonsense to state that Miranda is sterile bacause "she's partly synthetic", unless her sterility is due to the genes needed for having children having been removed from her DNA in order to give her "better" genes.
"Better" in this last sentence is used from a corporate point of view; for evolution, the best and most important genes are instead those related to fertility and survival, not to powers or skills.

 

I'm not offended at all since there's a lot of wrong with your 'basic biology'. 

 

Evolution isn't just about "survival of the fittest". That's an oversimplification of Darwinism from the 19th century being perpetuated for layman most of the time. (Nowadays folks usually use the word natural selection). Evolution is by definition a change in heritable traits of biological populations over successive generations. Its a general term that applies to all life forms even virus and bacteria. It doesn't solely means being horny is a desired trait. The desired trait in every generation is fertility and being genetically viable and not just pure sex drive. In fact, Ardat-Yakshi reflected this by having natural urge to mate except they kill their mates and also sterile. 

 

All of us have some sorts of mutation in our lifetime. For an example, an average person do at some point in their life will develop cancer cells (an error in apoptosis and genetic repair mechanism) from all factors from inhaling or eating carcinogenic chemicals, uv radiation, workplace contaminants etc. Its a game of chance whether your body recognize these cells and destroy them or the cells proliferate uncontrollably that overwhelmed the body's normal NK-cells immune responses and become cancer mass. But not every DNA mutation is 'deadly'. Your skin tone, eye color etc is a form of heritable genetic traits which is an actual physical mutation cross generations. And of course, the actual practical approach on human mutation and evolution was on the study of heritable diseases. And not every form mutations are deadly to the person or make people infertile. Not sure where you learn this though.

 

And I'm not sure how on earth you come up with the idea that "man-made = natural modication as equal in evolution". Actually not. Human inbreeding is man-made modification in familial generations and is evolutionary flawed. And I'm not sure you understand how human fertilization and genetic exchange works... but Miranda is genetically composed based on her father's DNA including his Y-chromosome embedded into her paired X-chromosome. His sole idea of creating his own dynasty was based on around his genes which he thinks included in his ideas of perfection. That is a completely flawed and completely megalomaniac. Realistically, she would have a similar problem with trisomy cases where she could have ovarian infertility. Oogenesis is a complex process that can be affected even by minor genetic defects on nuclear material and Miranda's genetic modification was aggressive that Javik even think she is unnatural. A lot of natural mutation in humanity can result in infertility, Miranda isn't immune to this.

 

And I do have an actual degree in biomedical science with a specialization in clinical biochemistry and molecular genetics. Yeah, I'm sooo 'cartoonish' with my basic biology. 

[Esthlos]

[...]
The desired trait in every generation is fertility and being genetically viable and not just pure sex drive.
[...]

 
Which is not what I wrote.
I was comparing the trait "bending space-time continuum" as an example of x-men like power to the trait "being hornier" as an example of something way more mundane that affects your offspring.
I also added multiple mentions of having your own children and them being healthy enough to have their own children exactly in order to avoid this misunderstanding...
 

[...]
But not every DNA mutation is 'deadly'.
[...]

Which, again, is not what I wrote: I instead wrote that mutations are random, and that evolution merely selects those that somehow ultimately affect fertility.

(As in
Helps survive until you have an offspring -> trait becomes more frequent

Directly improves fertility -> trait becomes more frequent

Reduces your chances of having an offspring -> trait is eventually removed

Doesn't affect fertility in any way -> trait is not directly lost but will accumulate mutations at random until eventually either those will affect fertility too or will be so many that they'll effectively cancel the trait)
 

[...]
Human inbreeding is man-made modification in familial generations and is evolutionary flawed.
[...]

Inbreeding is not man-made; genetic engineering is.
 

[...]
but Miranda is genetically composed based on her father's DNA including his Y-chromosome embedded into her paired X-chromosome.
[...]

You need only 1 healthy X chromosome to have enough DNA to give to fertile eggs; having healthy eggs to give that X to in that situation is another matter though, that's true.

Also, in addition to what you wrote, Miranda may be a case of this: http://ghr.nlm.nih.g...tivity-syndrome

What we do not know is whether she is infertile because she doesn't have an uterus, because her eggs are not fertile, or because she has no eggs at all.

But I fear I'm missing your point: how does Miranda having a medical condition (that can happen in non-engineered humans too) which causes infertility translate into Miranda being infertile due to being partly synthetic, as you wrote in your original post?
 

And I do have an actual degree in biomedical science with a specialization in clinical biochemistry and molecular genetics. Yeah, I'm sooo 'cartoonish' with my basic biology.

I'd like to point out that I judged your understanding by what you wrote, and not by your degrees.

As a side note, though I'm sure this won't be the case with you, sadly degrees do not automatically translate into actually understanding what you studied, homeopathic physicians being a clear example of this.

[aoibhealfae]

 
Which is not what I wrote.
I was comparing the trait "bending space-time continuum" as an example of x-men like power to the trait "being hornier" as an example of something way more mundane that affects your offspring.
I also added multiple mentions of having your own children and them being healthy enough to have their own children exactly in order to avoid this misunderstanding...
 
Which, again, is not what I wrote: I instead wrote that mutations are random, and that evolution merely selects those that somehow ultimately affect fertility.

(As in
Helps survive until you have an offspring -> trait becomes more frequent

Directly improves fertility -> trait becomes more frequent

Reduces your chances of having an offspring -> trait is eventually removed

Doesn't affect fertility in any way -> trait is not directly lost but will accumulate mutations at random until eventually either those will affect fertility too or will be so many that they'll effectively cancel the trait)
 
Inbreeding is not man-made; genetic engineering is.
 
You need only 1 healthy X chromosome to have enough DNA to give to fertile eggs; having healthy eggs to give that X to in that situation is another matter though, that's true.

Also, in addition to what you wrote, Miranda may be a case of this: http://ghr.nlm.nih.g...tivity-syndrome

What we do not know is whether she is infertile because she doesn't have an uterus, because her eggs are not fertile, or because she has no eggs at all.

But I fear I'm missing your point: how does Miranda having a medical condition (that can happen in non-engineered humans too) which causes infertility translate into Miranda being infertile due to being partly synthetic, as you wrote in your original post?
 
I'd like to point out that I judged your understanding by what you wrote, and not by your degrees.

As a side note, though I'm sure this won't be the case with you, sadly degrees do not automatically translate into actually understanding what you studied, homeopathic physicians being a clear example of this.

 

You're clearly deflecting and this discussion are nowhere near academical but I will entertain this for a while.

 

The primal need to procreate is for the survivability of a species and its successive generation. Its not a 'trait' manifested from evolutionary process like eye color, skin tone and even the increased risk of gaining certain diseases. X-Men is a fictional appropriation of the possibility of inherent genetic defects causing fantastical powers which is appropriated in human biotics in ME which in long term the trait can be hereditary like a mage in Dragon Age.

 

People can still create children through various intervention. Even now its possible for a child to inherit traits and genetic information from multiple parents through IVF. Miranda was proof that you can create a child with biotic traits. Even if biotics does have fertility problems, the ME verse science was able to circumvent that. 

Inbreeding is one of humanity first experiment in genetic modification. Much like the effects of human foraging in the evolution of modern crops, its effects is more prominent in the predisposition of certain genetic diseases in the gene pool. Just because its not created in a sterile lab, it doesn't mean its not science.

 

And you still need 23 paired chromosomes to create a living being but of course there's special cases with polysomy. One single healthy X chromosome does not have enough DNA to create anything.

 

Miranda condition isn't due to a hormonal defect. What I'm saying is that her DNA was artificially constructed to include various traits from various people based around her father's genome. This is like having multiple pieces of different puzzles being cut and paste together to form a living person based around the genetic struction of another person... and the opposite sex too. Miranda is a miracle of science much like Shepard's reconstruction process but in Miranda's case, her genetic structure was in fact very unstable. I reasoned it that she could have problems with formation of fertile ovum and reproductive organs is very sensitive to a lot of sudden changes particularly in the genetic structure of the female. This irregularity could increase a person of having other health problems. Although, she maintained that she is healthy, but from the sound of her doctor, she could develop a condition called benign epithelial neoplastic cysts which do occur among healthy females. From the sound of it, it affected her ability to conceive a child and her only option was adoption. And among her wishes for her twin was for her to have a family which probably means, the reason why her father created Oriana was because he found out about Miranda's infertility. Since there's no actual explanation for this, we could assume a lot of probable scenarios.

 

I don't usually like to point out that I have degrees on but it is a subject where I am passionate about. I do recommend you to read more on history of human evolutionary genetics, reproductive genetics and some aspects in advances of molecular biology.