Ah, that....well, that may be unrelated to the problem at hand. It probably has to do with the fact that I'm highly allergic to the social sciences' conceit that biology doesn't matter. Sure, they're not all like that, perhaps not even the majority, but I've met enough radicals to develop some rather unrelenting hostility and a suspicion of the whole field in general, a few selected individuals I highly respect notwithstanding. It's the same reason why I argue so vehemently against inter-species sex (as opposed to platonic love) in SF.
Perhaps the whole way people tend to argue about this is more liable to antagonize me than necessary. "Does it matter if someone has <insert sexual organ of your choice"? Yes, it absolutely does matter, and I think a transgender person would know better than anyone because they're fighting biological facts hostile to their self-image every day, don't they? If it didn't matter, they wouldn't need to fight. The more pertinent question would be "Should we let ourselves be defined by that"? Well, I'm a transhumanist, what do you think my answer is?
I should say this exchange has taken an interesting turn. Thank you for that. It may be I find it costs me little to use another's box next time the matter comes up in RL. We'll see.
"You humans are all racist!" *Turian voice*
Sorry, had to do that. 
Seriously, for me, it's not so much that I would consider myself or anyone in our community fighting biology so much as confronting the limits that some societies impose on a concept that evolves beyond it. Trans folk are at extremely high risk of violence, depression, and suicides in the Union alone, and in this country there have been several cases where the murders of such folk are often excused with arguments like "he/she was just pretending" or "they should've seen this coming." Islan Nettles, Martinez, and Brandon Teena(originally Teena Brandon) come to mind. I'm definitely not like some of the folks I've seen who try to discount biology- I also don't use the miniscule percentage of variations as some substantial "proof" either - or with pseudoscience, but as I posited earlier, we're in a time where gender isn't being always being used in a purely scientific sense, as I'm sure you'd recognize. When I think about those aspects or refer to them in discourse, I tend to use "sex" rather than gender; it feels more concise.
Since people seem to think we only like Krem because he's trans, I'll offer my reasoning:
When I look at Krem - he's not my favorite minor character, although I do like him alot- in DA, I see a person who escaped a life of slavery after hitting a slump, had their own misadventures in the military, was rescued by Bull, and later became a friend of his who, as it turns out, is the reason said person decided to join the Inquisition. Krem's very matter of fact, has a decent sense of humor and neither of the two allow the fact that their countries are warring with each other to conflict with their friendship, and they have no qualms teasing each other about their cultural differences. Krem's completely comfortable with his identity and evolved past the tired pariah-hood PSA and Lifetime depictions love to sensationalize. I think it's a testament to how well Hale performed that many players didn't even notice that Krem was trans - I have close friends who are also nadleh and live and identify pretty much like Krem does, so I thought so - until Krem made another joke teasing Bull's harness and claimed he'd show him how to bind his "breasts" properly. They're in a bar having a casual conversation, and the two obviously have a close friendship with each other, so where some people consider it abrupt, I felt it perfectly made sense. (EDIT: Note that this scene only takes place after you've completed Demands of the Qun and saved the Chargers. It stands to reason the Inquisitor's known Krem long enough to be acquainted with this information.)
Aside from a few of the choices the player had - which made them look like a complete buffoon - I appreciated that the choice to pursue any conversation on that matter was entirely optional; they can ignore it and continue the dialogue. Ultimately, Krem's identity is significant, but interactions with him do not essentially revolve around it. It's normal. That kind of acceptance is what many of us who don't have the privilege - yes, even transfolk can have privilege - to physically resemble the sex we identify with look for. We don't want, like so many in this thread have done - to be reduced to terms and bodyparts(there are plenty who don't even consider reassignment surgery). We're people, with lifestories, interests, likes and dislikes. Krem is a person first, trans second. Is he the second coming of maverick storytelling? No, well at least to me he's not. But he is a step in the right direction.
We may disagree on occasion Ieldra, and being a passionate debater I'm often an *******, but I always love hearing you share your own opinion, although I do miss those gigantic posts you used to do on the old forum. 