Missions I often skip:
Jack - no effect in ME3
Jacob - one line of dialogue is added if you do his LM, otherwise no difference in ME3
If I am feeling rather lethargic I might skip Garrus's LM because it has no effect in ME3. But generally I go and get the sniper rifle upgrade.
Thane's mission has only a small impact in ME3, and then only if you stop Kolyat. But since there is no fighting I generally at least go far enough in it to get the pistol upgrade, even if I don't bother tracking Kolyat.
Oh I could never EVER skip Jacob's mission. The neutral ending is just entirely too funny for all of that.





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