This is what happens when the game is developed in such secrecy
Well, at least we get some #space tweets, Fallout fans don't get even those as far as I know 
I'm waiting for E3.
Yep. BGS is infamous for never talking about any of there new games while in development. They like to reveal them right before they release, which was the case with Skyrim. It's a frustrating wait, but I understand the purpose in doing it. Certainly, it avoids a lot of PR nightmares and devs contradicting themselves when features don't make it into the final product. BGS made those mistakes with Oblivion (a lot of stuff was cut) and probably did not want to repeat it.
That's grasping at straws, in my opinion. We could assume he means something more than that. I have a feeling most of the devs at BioWare Montreal are probably just fans of science fiction and space in general. We'll find out soon enough if it's remotely related.
I have question for you guys...the synthesis option makes it hard to have a game still set in Milky Way (without having everyone have green eyes, etc) given that the 'space magic' seems to go from relay to relay and hence the whole galaxy. But would it hit dormant relays? ie, is it possible that areas of the Milky way that were not connected via live mass relays would be unaffected? Has anyone discussed that possibility? If that is possible, then it seems like remaining in the Milky Way and not being overtly affected by choices at the end of ME3 would be entirely possible. Thoughts?
This may belong in another thread, so if too off topic, just ignore me! 
The Citadel's discharge only seemed to impact active Mass Relays, so I don't believe it would have impacted all sectors of the Milky Way, as some assume. As far as Synthesis, for all we know, the glowing eyes could wear off after a while due to a temporary symptom of being imprinted with a new DNA. There's a lot BioWare could do with that.