Refuse is as much canon as Destroy or Control or Synthesis. Shepard dying in ME2 just didn't happen. Refuse could happen.
LOL
It didn't happen because Shepard is alive in the next game. Refuse could happen because we haven't got the new game yet. If the new game does not acknowledge Refuse as a viable choice then it didn't happen. Simple as that.
And Refuse was added by the Extended Cut. What about players who don't use it?
You did, you just ignored it.
Staying in Milky Way:
pros:
- You can visit already established and loved places like the Citadel or Omega etc.
cons:
- They have to canonize endings or avoid it, but in that case it would be very constarined.
- The lore is sucked dry, there is no conflict or potential left in it.
- All the mysteries are gone. We know everything about the explored galaxy. Protheans did this, Reapers did that etc.
- If it's not in the explored galaxy then what does it matter if it's in the Milky Way or Andromeda? Same ****.
Going to Andromeda:
pros:
- Brings back the mystery.
- Lot of potential for new lore.
- Doesn't trashes your choices in the trilogy.
- Lots of freedom for the writers.
cons:
- Not seeing the loved places again, but if that's such a huge issue for you just replay the damn trilogy.
- Potentially playing loose with lore.
It seems you are the one ignoring what I'm saying.
Staying in Milky Way
Point 1: No need to change or add new lore to explain getting to the locations where the game takes place.
Point 2: please, explain why it would be very constrained
Point 3 and 4: Same potential for conflict, new lore and mysteries - less than 1% of Milky Way is explored (codex)
Point 5: see point 1
Notice that I don't advocate for returning to the places of the trilogy
Going to Andromeda
The only difference from a secluded space in Milky Way is that it requires establishing new (and retconning the old) lore to make the journey possible. Or use some space magic plot device.
As you have pointed out yourself, setting the game in an unaffected region of Milky Way is the same as setting the game in a new galaxy. The only difference is that there is no technology for intergalactic travel in established lore and they'll have to make up something to make it plausible.