First off, I loved how ME2 directly and heavily referenced ME1 during its early hours... then IGN had to criticize it for being hard to follow as a newcomer and the whole "ME3 is for newcomers, come in everybody!" mess started. I didn't like how ME1 or ME2 was referenced early on in ME3. It felt like ME3's perception of the events from 1 and 2 was too diferent somehow. The fact that Shepard acted different and Anderson's characterization was off had something to do with it too, I'm sure.
I still don't know what to feel about MENext, but then again, anything would be premature as I haven't gotten a feel for it as there is not even a trailer yet (and that pre-alpha from last year is nothing to judge by).
Sometimes though, I do wonder if it's time for a deconstruction of the Mass Effect IP, but I don't know. I kinda like the idyllicness of all species talking english and inter-species relationships but I do think you could make a good story out of exploring the fact that humans and aliens are biologically, culturally and... sapiently(?) unlike each other and there should've been more repercussions to that.
KOTOR 2 became one of my favorite Star Wars plots of all time because of how it deconstructed the IP and questioned the ethics behind being a Jedi or Sith and being capable of using The Force.
I'd love to see Mass Effect question its own properties a bit more but I wouldn't want it if it was corny, like Uncharted 3 was to the other two (remember Drake's existential crisis and all that? Not so convincing.) and attempting to deconstruct something is a huge risk to take.
But I'd take it any day over more mercenary plots, edgy and dark Cerberus crap or "humanity can overcome all odds, oorah" that the series has got going for it since Mass Effect 2. (Reaper plot had some decency to it, I admit though, if we can put aside the ending itself)
If this Andromeda Galaxy colonization thingy ends up referencing ME3's ending at all, I would actually love it if it was like "we stay away from Milky way because it is infected with synthesis!" but either way I don't see it making any sense, so buck it :-3