Some were, yeah, but it could still potentially be made into a prequel to Fallout NV. Like that war between the Brotherhood and NCR
Yeah, the war could be explored in more detail, since it's only casually addressed in Fallout 3 and New Vegas.
Speaking of the BoS, I wonder if siding with the Midwestern Britherhood could make Boston a beacon for the more traditional groups within the Brotherhood, especially if they veer more towards the Western approach to the Codex and the acquisition of technology.
Given how the NCR has stabilized and grown so far, they might want a place of their own (and they may oppose Lyons' more radical approach to the Brotherhood, despite his successes).