It depends on what you consider a success I guess. Vault Tech didn't care about humans surviving. It was experiments that they cared about. Even Vault 8's assignment could be seen as a failure if you play a horrible PC and kill everyone possible in Vault CIty. That's the freedom of the FO series.
So House DID ruin the experiment of vault 22 (which was all about gambling)
When it comes to Vault 21 (vault 22 was the one with mutated plants), it did suceed, not only in keeping it's ocupants alive, but also in it's experiment, were every issue in the vault was to be solved with gambling, and then everyone lived in a rather utopic anarchy.





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