The Milky Way has so much more potential, with over 300 billion stars. We could explore different star systems that were left untouched by the Reaper invasion. Traveling to the Andromeda galaxy is just so... out there. Intergalactic travel? Please.
The multiple-choice ending paradigm doesn't work. I wish game developers would stop doing that.
Agreed on the first statement.
I do think multiple-choice endings can work just fine, but it depends on the scale. You can have a very involved smaller-scale game with all the things Bioware is good at and known for, and have radically different endings in that. Make the next story/game set apart enough and you can respect player's choices and refer to them and see some consequences.
It gets different when said consequences affect the *entire* galaxy you're in. I don't think abandoning different endings and choice-consequence is something to hope for, but if a developer goes that way they need to think it through, plan it out, and see what works to keep future games workable in the setting. This was obviously not done properly in the case of ME3. ME2 managed much better though, and still had quite a few choices that affected stuff down the road. They just upped the scale too much so that the consequences aren't containable and aren't able to be reconciled in the next installment. Shame, but it's what they have to work with now. Any way forward from that will displease people. I'd rather see a canonized ending and stay in our galaxy, but that's just me, it's safer for them to do this, so I get why, but I think it's a huge waste.