I suspect the factions will be completely new, with the possible exception of Cerberus.
I would assume the Geth could make an appearance in some form or another, but then there's the whole issue of whether that canonizes one of the endings of ME 3 (obviously "Destroy" is out if the Geth are still around.)
A lot of the existing species could easily be worked in somehow, so there are plenty of possibilities as far as character and kit selection.
And then there's the big question: Horde mode? Perhaps something seamlessly mp/sp, the way Dead Island worked? It would definitely be nice to play an SP style mission with other people, rather than defend a big box with the attendant spawning weirdness.





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