Not comparable.
The Lazarus project? Yeah, that's utter nonsense.
So what then, we need even more monumental galactic nonsense to hammer it home, eh?
Mass Effect is utter nonsense from start to finish.
Almost none of the technology shown has any chance of working. Ever. Unless you change all the scientific laws. The relays? Millions of years old relics that each hold energy comparable to a super nova... and they never ever run empty, no matter how much traffic they handle. Oh, and they accelerate ships to far beyond lightspeed... how exactly? There is no warp bubble, there are only mass effect fields which are dark energy manipulated with electricity to generate gravity effects. Somehow. That's like saying a wizard absorbs mana from the environment, stores it in himself and transforms that mana into destructive fire spells. Neither has any basis in reality. It's pure fantasy.
You can easily deconstruct every single piece of technology presented in Mass Effect, almost all violate at least one law of thermodynamics. Especially the weapons.
There are certain tropes we accept, tropes we can suspend our disbelief for. For example... scanning planets from orbit and getting accurate data instantly. Tropes like that are okay.
But magic space Jesus saving the galaxy by spreading his molecules throughout the relay network and transforming everyone into a organic/synthetic melange? Yeah... that makes no sense at all. Not even remotely. Or Control ending, where you have to be disintegrated to be uploaded as AI. Because a dying organism makes for such a good template to copy from...
Seriously, I could drown this thread in examples, so let's summarize: Mass Effect is futuristic fantasy. It is not science-fiction. That's not good or bad, it just is. Personally, I had fun playing the trilogy over and over again (ME3 only twice though). It's similiar to Star Wars, which is mindboggling stupid... and still totally awesome. Because it's fantasy. In space. And not science-fiction.