The effects of the Crucible only spread throughout the Milky Way relay network, so the Andromeda galaxy should be unaffected by it. Whether or not the Milky Way colonists should be affected by the Crucible depends on whether or not they departed the Milky Way before it was fired.
For what it's worth fan speculation is that the colonists leave before the end of Mass Effect 3, as that allows the devs to sidestep around having to deal with the widely diverging ending results. Assuming this game is set in Andromeda for exactly that purpose, which seems very likely, it is probable that the devs would have the colonists leave before the Crucible fired.
Pretty much my thoughts exactly.
I guess the colonists could have left after the Crucible fired because of some unforeseen effect from it but then the devs face dealing with the endings of ME3.





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