MMO's about the only one tbh.
So long as it's good I don't really care how they get there.
FPS.
MMO.
Set protagonist.
We're still good so long as those are out of the equation.

Now, why the hell would they even do that, lol?
Okay, I think according to our common criteria ME:A is probably not gonna end up being skipped by any of us.
Here's a few of mine:
I wouldn't buy the game if...:
- too much dabbling around in how it connects to the events of the trilogy i.e. continuing to retroactively try and justify the ME3 ending or Crucible or Leviathans. That ship has sailed.
- If the plot actually ends up ME1 in new clothes.
- If all pre-release teasers and footage sledgehammer the point of the game as if it's all about humanity and appeal to us as if that's what we think is cool about Mass Effect
- Massive amounts of autodialogue, lack of cinematic conversations.
- Main story that takes up 15-20 hours while you end up spending 50 hours on grinding and clearing objectives that don't leave an impact on you.
- If the game has as many glitches as DA:I on launch I will avoid it for a month or two
- no classes.
- environments that are as video-gamey as DA:I's (e.g. The Spooky Area, The Snow World, The Forest World(s), The Desert World)
- MMO level-design (meaning, if the objectives in the world in conjunction with the world-design is based around time-sinks rather than good contextualized world-building and NPC characters that leave a mark on you)
I don't remember characters like Mouse from Mass Effect 2, but at least I remember that his name was Mouse and that he was the guy I was looking for with Thane. I doubt I would've remembered any of that if it wasn't all cinematic or the camera angles put emphasis on sort of an empathy for Thane and what he was thinking. I actually think the lack of cinematography in DA:I was my biggest dislike along with the lack of good quests and the whole design around questing.