My dislike of space magic in, say, Mass Effect isn't so much the space magic existing. I actually love a lot of scifi that goes into 'science' that is practically just magic by our understanding.
Mass Effect 1 - Very little space magic, though it was present. For the most part though, Bioware tried to explain themselves.
Mass Effect 2 - A little space magic, and it irked some people. What is 'genetic destiny'? What is 'deconstructive analysis to make a Terminator robot?' Why can't Bioware properly explain the plot, and the science of it, of their single game instead of leading us on for answers for the next game?
Mass Effect 3 - Wow they just aren't even trying now. SomethingsomethingrelayssomethingDNAsomethingsomethingquantumphysics. I'm sure there was science involved in everything, including Synthesis. But it rose up to a spiritual-faithful('just roll with it')-transcendental level that, ugh, just annoying, go away Synthesis, you're weird.
Now, I dislike this. BUT, I'm also crazy enough to think this is all intentional and part of a larger plan. BUT, I still think this is WEAK for each game taken as single games. It doesn't make me want to buy your single games. If you're going to do this, then stop pretending to be the ending of a definitive trilogy, and be open with the fact that you're trying to make chapters of a larger story that will continue to have questions and (importantly) answers.
If MEA has full on space magic, I hope it is still explained well enough in the single game. I can accept the Cypher, for example, if I can accept the idea that the Prothians used technology differently but understandably. This worked in ME1. The Crucible? Wtf was that haha.
In the end, I actually love space magic, I gotta admit. My first choice was Synthesis. I was fascinated even in ME2 with how the universe may be viewed by the Reapers and what really makes them. In another sense, I absolutely adore the Dragon Age: Inquisition changing take on the Fade and reality. Love it love it fuels allll my speculationz.
But it annoyed us in Mass Effect, by the end. It was too weird, in its placement in plot. It made us not enjoy our experience. Fine, its art - I even love the idea that this is very much a psychological experiment put on the player. Okay. If that's the case, then this is the time to (in the spirit of ethical experimentation) reveal to the subjects that they were in an experiment and promise to not do anything much like this ever again, so we can enjoy your games without feeling so manipulated.
Space Magic = can be good
Space Magic feeling meaningless = just get off the stage...ugh