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Let me see...
2. "... destroyed that universe..."
No such thing occured. The Milky Way galaxy is alive and well. Depending on the choice you made,
1a. Destroy.
The Reapers are destroyed along with the Relays, in which case galactic travel is now slowed downed to a crawl using primitive FTL drives,
which, if I remember correctly, is about 15 light years/day. Races survive and go on and the stars remain.
1b. Control
You control the Reapers. Galactic civilization continues, the galaxy continues to exist.
1c. Synthesis
This changes all life in the galaxy. But, the Relays survive and the stars are still there.
Shep dies, the trilogy ends with a fan base up in arms about how the end choices were presented, which, frankly, were pis* poor endings. A fourth Mass Effect game could not possibly be played in the Milky Way because of the three different endings and the fact that many wanted Shep back.
The best reasonable approach is to leave the Milky Way galaxy behind and start anew.
I'm not sure what your expectations are regarding sci-fi games, but Star Citizen is the new Wing Commander coming out this fall.
"destroyed universe" ofc i didn't meant that ME3 ending physically destroyed fabric of the universe. It destroyed "universum" -- franchise, lore of ME. there is practically no logic possibility to create one consistent game that would have logic cause or reference to co much damaged "universum"
why? here you go:
First -> We had 3 different endings that split fate of our galaxy so no simple continuation is possible.
Second -> Reapers problem was not solved at all. It was solved locally, but reapers are, what we know about them, universal beings. From simple calculation of their probable lifespan and their FTL speed they could have travelled almost of the edges of visible universe(13 billion LY) local group of galaxies is just small backyard for them. If there is so, there are much more reapers lurking in dark spaces of the universe.
Third-> To solve our little problem (in scale of the universe Milky Way is just scrap of the dust) we just used one shot gun. There will be no second chance in any ending because if reapers come back they will be aware of that solution.
Bioware just dropped into their own pit. They wanted easy money with ME3 and used most ordinary, ugly, primitive, solution: take big, enormous gun and kill the villain. In fact big brother of the villain is standing behind the corner and they have empty hands. ouch time