Apologies for butting in.
I will never understand the argument that moving the setting to a place far enough away that our previous choices don't affect anything is somehow "throwing it to the wind". It makes no logical sense whatsoever.
A choice does not automatically lose its value just because it never comes up again.
You bring up a point that's been bugging me since the game came out actually. Why does a choice in a video game have value to begin with?
Personally, I think it's when it has consequences that surprise you long after you've made it. Choosing to rewrite the Heretic Geth is a good example of this for me. The Paragon choice of leaving them alive actually has unexpectedly negative consequences in ME3 because it makes reconciling the Quarians and the Geth more difficult. Even though I had made the 'wrong' choice here, I actually enjoyed being thrown a bit of a curve ball.
The ending choice, by contrast, is far less interesting for me. It's supposedly galaxy altering effects are limited to the last 10 minutes of the game, and a slideshow at that. There's also no surprises there; you pick the choice that kills the Reapers? The Reapers promptly fall down dead. You want to combine organic and synthetic life? Everybody obligingly gets green circuit board tattoos. All the options do exactly what they say on the tin. No surprises, pleasant or unpleasant... I just find it oddly superficial and throw-away, really.
I think this gets to the heart of my (and perhaps others' ) frustration with the move to Andromeda. If the RGB choices have no interesting or surprising consequences that we get to live with in the next game, then what was the point of making them? I just think it's a shame we'll never get to visit the Citadel, Rannoch or Omega again, largely because of one, really rather lacklustre, 'choice'.
Destroy is stupid on so many levels, Synthesis is basically raping every lifeform in the galaxy with nonsense, Control at least attempts to keep assets for rebuilding and preventing future issues (while also being stupid) and Refuse is the perfect choice because the our cycle was too stupid to live and deserved to be harvested.
I know that you're joking a little, but ironically I think Refuse is the most compatible with the plot of Andromeda for me. Because unless the Alliance lost the war, the Milky Way is a wasteland and these are the last human beings in existence, why should I get particularly concerned about the trials and tribulations of a few thousand colonists in the suburbs of andromeda?
I'm exaggerating a little, I'm sure if the new characters are well written people will get deeply invested in their fates, but it's still a bit of a come down from saving a whole galaxy full of civilisations that have endured for thousands of years. At least if these colonists were all the last of their kinds, and in danger of being wiped out by these 'Khet' things, there would be some sense of jeopardy about the enterprise.
It's a damn shame. Refuse has my favorite Shepard speech. But I still can't choose it, ever. 
I know right? It's a fantastic speech. Shame about the immediate aftermath...
Edited for spelling and clarity.