I have never tried the Spitfire on the Destroyer, because I always assumed that the movement speed penalties from the Spitfire and Devastator Mode would stack. And I find that being able to move helps with gameplay. My assumption could be wrong though.
Also, I use the Spitfire so much on the Juggernaut that I don't really want to use it on anything else. It just works so perfectly on the Juggy with Incendiary Ammo - the Spitfire strips shields pretty quickly, and then you can Siege Pulse everything for a bunch of Fire Explosions.
It's a strangely fun build, though that could be because I have the sense of humour of a 10 year old and find watching the Destroyer running like hell and going slow all over the place pretty funny. Not to mention the massive amounts of ammo that let you basically fire nonstop for the whole wave.
That said, it also actually is fairly effective as a build. Not on the same level as a Typhoon, but you can still actually be useful, while looking and running around like an idiot.