I suppose the question is, how does ME:A relate to the previous Mass Effect games?
1. Does it follow up on the characters? No, those characters are finished.
2: Does it follow up on the setting? Apparently not, as it takes place in a completely different new setting in another galaxy.
3. Does it follow up on the storyline? Maybe, if the previous events in the story somehow lead to whatever it is we're doing in this other galaxy.
4. Does it follow up on the themes? Maybe, but I don't see it. It seems to me that they've said all they had to say about it, and in the end it wasn't very good.
5. Or... is Mass Effect just guns, biotic powers, and yellow light gauntlet thingies, and as long as you have that you can just stamp the logo on it and call it Mass Effect?
It's weird to be so unexcited about it. A new Mass Effect game used to be something that I couldn't wait for, now it's only something that I'm mildly interested in. But who knows? Maybe it will be brilliant and the next one after that will be something to look forward to.