It confuses me sometimes how there are people that believe that the Genophage is inherently evil, and that it was cruel and unnecessary. I blame a lot of this on the fact that the player is unable to experience horror the Krogan Rebellions themselves, and them spreading throughout the galaxy like a plague that seemed to be unstoppable.
I also imagine the image of so many krogan children being stillborn to be a horrible, and one that is very hard to reconcile with doing the right thing.
But consider Mordin for a moment. I admit I may be a little biased because Mordin is probably my favorite character in the series, and even I will admit that his heroic death in ME3 was a tearjerker. You also have to consider the fact that, without Wrex or Bakara still alive and able to lead the krogan, Mordin can actually survive, realizing in the end that without the proper voices to lead them then the krogan are beyond saving.
But what if someone, after the galaxy was saved and reaper threat was eliminated, assassinated Wrex to take control? Is this not the type of culture that the Krogan espouse in the first place, a sort of klingon promotion that ensures the strong are always in the lead?
If Wrex died on Virmire, then we have Wreav in charge of the krogan, who is an even more immediate problem. Wreav, who, after the genophage was cured and the krogans are no longer needed to fight the reapers, had explicit plans of mustering a krogan army to declare war on the citadel races? If Bakara is still alive to act as a stabilizing force, even then all we have is the assurance that if Wreav did so, there would be a massive civil war amongst the entire krogan race, possibly only postponing the inevitable if Wreav or some likeminded krogan were successful in the end.
The game went through great pains to show us that Wrex is a cut above the rest when it came to the krogan. He represented what they could strive to achieve; he was a powerful battlemaster, but still has hope for the future of his species. The rest were mercenaries and brutes, and through no fault of their own. Grunt was introduced in part to give us some insight into krogan biology; harsh life on Tuchanka has made them incredibly resilient killing machines and they have an unquenchable rage that can only be held in check with a sense of clan and a steady supply of enemies to fight. They also possess an incredibly fast rate of reproduction that was necessary because, on Tuchanka, most krogan never lived to see adulthood.
What happens when they run out of enemies to fight? Because they will certainly never run out of krogan.
I really doubt I will be changing any minds, but all to often I have been called a "colossal dick" for my decision to not cure the genophage. The idea of the genophage has had far too much time to entrench itself as a terrible idea in the eyes of the fanbase, and it has way too much real life parallels to eugenics programs weighing it down to have a sensible discussion. But people need to realize that curing the genophage is never exactly a no-brainer choice. I personally never would have cured it even without the incentives from the salarians.
If given a choice, the only other outcome I would see as solving more problems than it creates is weakening the Genophage to the point that the Krogan are able to survive as a species, but not removing the genophage altogether. It would be a terrible thing to lose an entire race such as the Krogan to their own stubbornness. Despite all of their flaws, they saved the galaxy from the Rachni, they have a vibrant culture, and the tend to be fun at parties.
Disclaimer: I don't metagame, meaning that I never make the decision of whether or not to cure the genophage infuenced by the fact that the synthesis ending would probably make them more intelligent and cure the genophage in the process, or the fact that by controlling the reapers we could probably put down any future Krogan Rebellions in like a month.
You may now proceed to call me a colossal dick.
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