No it doesn't. In the world of head cannon which seems like 8 out of 10 destroy option pickers live in yes.
What's wrong with the "world of headcanon"? It's only a good thing in my book, it means that people actually think about the game they've played and don't take anything at the face value, they try to dig deeper in search of understanding. It's not official, definitely, but nobody imposes their headcanon upon others, no? Speaking of official canon, I would be interested to hear how Synthesis is technologically possible if we use only the information from official sources to explain it? It:
1. Spans the whole galaxy (or at least 80-90% of it based on the final cutscene)
2. It changes the DNA of all organic beings in the galaxy, even plants are changed
3. The change happens fast enough to affect Shepard's crew members
4. The only visible change is the green circuitry but the perception of individuals is drastically changed (EDI's I'm alive)





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