So I've heard a lot of really cool theories flying around here and other parts of the web ever since Trespasser dropped, and thinking about them all I started wanting to come up with a way to make it all fit together, if it indeed does.
We know from all three games that lyrium is pretty potent stuff for mages, I'm assuming this was the same in pre-Veil times. We learned in DA:I from Bianca that the theory some Smith Caste dwarfs hold about lyrium being "alive" was true because the red stuff is blighted and blight only affects living things. Then in Decent we learned about the Titans and found one that seemed to have a lyrium heart and "untapped veins" of the stuff all around.The takeaway from that is that lyrium is linked to/produced by the Titans, with the most common analogy being that its their "blood". From Trespasser we visit a Qunari mining operation and learn that Mythal killed a Titan (or multiple Titans) and rendered their demesne to the elves.
So what if just like death causes a mortal body to putrefy and decay, death does something similar to Titans? Their "blood" goes bad somehow. Blue "normal" lyrium can mess up people pretty bad, and we know the red stuff is even worse. And we know the blight spreads. What if its a disease born in the blood of a dead titan that can then infect "living"/blue titan blood and even mortals just like real-life blood borne pathogens do. We know the blight does exactly this from all three games. We also know the red stuff may be even more potent than the blue stuff. I think Varic calls it "like comparing a lizard to a dragon".
So Mythal kills Titan(s), the Titan "blood" goes bad, Mythal realizes this is an AWFUL idea and tries to seal up the "mines". However since the red stuff is so powerful the other Evanuris want to continue messing around with it. This is why Fen'Harel claims they "would have destroyed the world" if he hadn't put up the Veil. So Mythal tries to stop them from using red lyrium and in response they murder her, as again Fen'Harel says "in their greed". Solas of course is not very happy with this and seals them in the fade to both stop them for playing around with the blight and to avenge Mythal.
Since we know the great works of the ancient elves functioned because the fade and the waking world were one and the same its likely their great capital of Arlethan was the same. Lots of people think that its the Black City and I think they are right. Solas locks the Evanuris in Arlethan and seals it within the fade. The mad God-Kings want out so they resort to experimenting with what stocks of red lyrium they have with them in the city but still can't get out. This overuse of blight power may have refined and supercharged the taint for what was about to happen. Thousands of years later 7 magisters of the Imperium decide to breach the Veil and enter the Golden City, upon being exposed to what the Evanuris were doing in there trying to get out the humans are tainted and manage to escape in their horror. Upon returning to Thedas they start spreading the taint to other mortals and First Blight starts when they corrupt Dumat.
Of course this theory as is has flaws, namely seven gaping dragon sized ones called "how do the Old Gods fit into this?", but I think it ties together some of the biggest mysteries of the setting in a way that logical and consistent with what we know up to this point.





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