What big aspect of the lore? Discharge? Who do you think cares about that except for a few nerds here? It couldn't even be considered a minor plot point since it's never been part of the plot of the series.
So because you don't care about that extremely limiting aspect of mass effect technology, it doesn't matter?
Apply the same argument to the Final Fantasy games. There's no writ rule here that sequels have to take place in the same setting, with the same characters, and the same this and that.
The FInal Fantasy games are part of the same series, whatever that means, but they are not sequels to each other.
I mean, by that logic, you could argue The Martian is a sequel to A Princess of Mars.
But tell you what. If the games are as separate as the FInal Fantasy games are from each other, as in no references to previous stories at all (as in, the original trilogy may as well never have happened. No Shepard, no Reapers, no Illusive Man, nothing) and this is a totally separate story with similar game mechanics and a guy named Cid who keeps popping up in a different incarnation, I'll accept that. New setting, new rules, and all.
But one mention of "The Shepard", of the Reaper War, or Protheans, and they've got themselves a problem.