I'm gonna go with no on this one. The Warden? It meant something...and it resonated. Third game? Warden is STILL being talked about. Now Hawke...the choice REALLY seemed senseless. They built Hawke up as this game changer, then demoted them to NPC. THEN gave you the choice to leave them behind, to hold the line...with a big fat MAYBE next to them. Will Hawke even be MENTIONED in the next game? No, seems they decided to tie that up pretty well. Considering that if you saved Feynriel, you have an EXTREMELY powerful Dreamer who could have guided Hawke to ANOTHER Rift or helped fight off the Nightmare. If Anders was alive, you THINK he would have found a way to rip open the Veil to save Hawke? Or Merrill? Or Bethany? If Alistair was left, well, he OR Loghain were tough as nails. Loghain in particular was a grizzled old war horse with little to lose. Stroud...well, okay, Stroud was probably screwed, but the others? Felt like a waste. Also, if they HAD gone with the Warden instead...I had a mage who seemed to exist half in the Fade ANYWAY...what was stopping them from just stepping through and back into reality? Cole did it! A Fade walking death machine shouldn't have TOO much issue with such.
If there is going to be a death, it has to have MEANING. Not just shock value. Killing the Inquisitor would have to have meaning. After all that happened, the only way I could see it having ANY meaning is if Solas himself did the deed. To show that he had FINALLY crossed that Moral Event Horizon and there was NO way you could redeem him. OR...that one act that finally breaks him into submission. Accidentally killing his best friend (AFTER he'd killed Mythal), sending him into utter despair, with him begging to be released from his life (watch though if they did that...it'd probably be the final ingredient in his 'torch the world' plan). Random mook number 7 wouldn't cut it. Even one armed, the Inquisitor is still a threat and exceedingly dangerous (especially a mage or stabby, stabby rogue).
Death with meaning, or heroic sacrifice. No 'ifs', 'maybes', or 'possibly' dead. Do it right, or go home, ya know?