You really think Bioware would swap galaxies if they still had to deal with ME3 ending repercussions?
Maybe. The Reapers pushed the scale of the stakes in the Milky Way to the max. Everything else there would pale in comparison.
Andromeda resets the stakes and instills a strong sense of "new frontier" exploration that simply wouldn't be the same in corking open old relays across the galaxy that we've bounced across in every which direction. Let alone the fact that this move will also reevaluate and potentially reset the variables accrued across the entire trilogy, not just in the ending. Even if the Reapers simply went boom at the ending, BioWare would still have a lot to variables to continue juggling.
Plus, there's the simple fact that the idea of exploring a new galaxy is, well, pretty darn cool.
Somehow, it still gets me excited. I love the theme, but I'm concerned whether BIoware has any audacity about it or if they're just trying to be Interstellar The Game (...And High-Spectacle Gunplay + Romance-Simulator). I mean, you gotta ask, is this really some video-game writer's own ideas or is he too in awe of his favorite movie?
I also got the Interstellar vibe from the trailer, but let's not pretend as if the ideas in Nolan's flick were in any way original. The most original aspects of that film came in the real-world science and the bonkers ending, which was also the part of the film that stretched credibility way too far.