When I craft something. The middle crafting item (the main one), example: 19 surrounded by two six's. I find it determines the strength of what you are crafting. (higher dps and more damage in staffs) You can fill in both six;s with a lower level crafting item like : canine leather level 1 instead of level 3 snoufleur skin because you don't have enough. per ce...
Will it make a difference in the end product unbeknownst to me. 
So, are you stating this, or is there a question?
Oh the right side of the screen you can see what each item adds. A tier 3 material will add more attack % (for example) than tier 2, which is itself higher than tier 1. The various materials add different bonuses: attack, armor penetration, critical chance, and so on. You can use these to customize your character's combat build any way that you want.
To summarize, all of the materials are actually significant, and if you do care about the stats on the weapon or armor you should choose them more carefully. But you might not, and placing them in there willy-nilly is fine too if that's what you prefer to do.
Yes I see what you are saying nightscrawl. What I'm asking serxa is if you usae a level 3 crafting material and themn surround it with level 1 it will make a difference in the stats I see that, but will it make a difference in the over all product. Will it be an inferior product that I cant see, the stats with standing.
level 2 plus two level 1's...as apposed to a level 2 and two level 2's
will the latter product be better then the former?
...maybe you should look at the crafting system again. It's a rather clear thing.
Using Tier 3 instead of Tier 1 increases stat/resistance bonuses.
Well obviously my question is not clear. He!
If you fill the main slot with a tier 3 crafting material, but only fill the other two slots with tier 1. Because of lack of material.
And fill the main slot and every other slot with a tier 3 on another crafted item.
Will you end up with a cheaper item over all, besides the stat difference.
Will item one be just as good as item 2, in the long run?
BTW: if you don't get it, then don't worry. 
I believe the answer to the first is no. It's the main slot that matters (not that it really matters, crafted items are sold for peanuts no matter how good they are).
As for the second answer, that would be a no. Those secondary slots can (at least IMX) make a real difference both short and long term. Those secondary slots are why (just to name one example) why the Staff of Lovias is so good even though there are other high grade staves that do more base damage (by having one or two more materials go in the main slot).
No crafted item is worth much in gold.
Better tier materials have better stats than lesser tier materials. Always try to go with better tiers.
Ultimately the crafting only makes a difference if you're a professional player looking to get the maximum damage from a character, and that is mostly about the masterwork slot and materials.
Better materials will make better gear. Also, the more material the schematic allows you to put, the better the overall stats you're going to get.
For example, a 12-material offense slot will give better stats than a 6-slot one.
You can see the material properties in the corner as you're crafting. It says something like "+1.75% Cunning". I don't know if I'm right, but I'm assuming it's +1.75% per material. So if you can put in 12 instead of 6, then you're going to get more of that bonus.
If you have great materials but not quite enough to make a full weapon/armor, I suggest you don't waste it on low-level schematics unless you really have to. Save them until you come across a better schematic.
There is NOT some sort of hidden bonus for using materials from the same tier, if that's what you're asking. The stats you see when crafting are the stats the weapon has, and that's it.
Here is a way to visualize it...
Weapon A - tier 3, tier 1, tier 1
Weapon B - tier 3, tier 3, tier 3
3 + 1 + 1 = 5. To average this out you divide by 3 for the amount of slots; 5/3 = 1.6
3 + 3 + 3 = 9. 9/3 = 3
So, you can see weapon A is still an inferior product either way.
Now, another discussion you can have is whether to use higher end mats on a low quality weapon. Let's say you REALLY like the Longsword of the Dragon and want to craft the T2 version as soon as you arrive in Skyhold. If you have T3 materials, you can use them to craft the T2 sword -- or any lower weapon -- to extend the life it would normally have as a typical T2 weapon with T2 materials.
Some people would say this is a waste, I'm sure. But it's your game, and you can use the mats however you want. This is especially true if you're on PC and can use Cheat Engine or mods to give yourself more gold, mats, etc. It's also dependent on the difficulty you play on. Someone who plays on Casual (like myself) can be less concerned about the stats of a weapon and focus primarily on looks, whereas it's less practical on Nightmare.
Well obviously my question is not clear. He!
If you fill the main slot with a tier 3 crafting material, but only fill the other two slots with tier 1. Because of lack of material.
And fill the main slot and every other slot with a tier 3 on another crafted item.
Will you end up with a cheaper item over all, besides the stat difference.
Will item one be just as good as item 2, in the long run?
BTW: if you don't get it, then don't worry.
An item that is made of a lesser material will always be of lesser quality, no matter what slot the material is used in. Use Tier 1 in just one slot, it's already inferior to it's full Tier 3 (or 4) potential.
One slot does not affect the other slots in an item.
Tier one materials give the lowest stats, whatever stat that might be in whatever slot and, tier 4 materials give the highest stats.
Then you can use masterworks materials (fade touched) to give an additional bonus or boost all stats on the item - That is the only slot that will affect the others and, then only if you succeed at crafting a Masterwork and get the 10% stat boost for the entire item.
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