Not really. They both suffer from the same issue of resolving the quest by clearing a place of X monsters and finding X object. Also, while Vault 81 had more people around then the Storm Coast none of the people there were really that interesting or memorable beside maybe Curie.
When it comes to dialogue Fallout 4 is a pretty bad copy of Bioware's dialogue wheel. No matter who your talking too all you get is Question/Maybe/Good Guy Yes/Bad Guy No. That's it. It's even more limiting then Inquisition where at the very least you could ask a bunch of questions and sometimes got the Sad/Angry/Confused/Surprised/Agree options. The paraphrasing is also terrible. The sarcasm option is utterly non descriptive and you can't even guess what the hell your character is about say. Will it be offensive, tough in cheek, cynical? Who knows.
And don't even compare the cutscene quality. Inquisition beats Fallout 4 easily in that park.
Honestly, if you still want to rag on Inquisition some more I'd suggest you just go back to that be more like Witcher 3 thread. Fallout 4 isn't the best material to work with.