I would prefer to face a boss that behaves in a completely different way than what we've seen so far.
A boss that can react to your fighting style and can respond in a more tactical way. I don't want a boss to behave like an average enemy grunt as they should have a special quirk which sets them apart from the rest.
For example, you could have a boss fight on a space station (but instead of fighting the boss in one room, you could have the entire station as the conflict zone). If the boss takes damage then they would have the opportunity to retreat to another area and recuperate or leave a trail of strategically placed mines/traps.
One of the interesting boss fights in the previous games (in my opinion) is Tela Vasir because there were many different elements involved such as; her escape, car chase, hostage and the final fight. So if they do keep to the same formula, I hope they will keep it up to the Vasir standard.