Does anyone remember in ME1, Ash talking with shep down in the cargo bay about her first field training exercises, and how she jumped out of the shuttle onto a planet's surface -- sorry, the name of the planet escapes me -- and she thought, "I'm the first human to set foot on this planet."
However many new planets there are to discover in Andromeda, we will be the first humans to set foot on them. I know, I know, the Milky Way is so incredibly vast that there have to be thousands of planets we haven'tZzzZzzzzzzZz
For us there will be much that is familiar, in terms of technology and biotics and those who come with us to Andromeda. And honestly, the fact that we see someone in the trailer wearing N7 armor would at least suggest an Alliance military structure and hierarchy onboard the ship, right? So what we bring with us will be the familiar, all updated and shiny and new in a new current-gen engine, and what we discover and encounter and interact with will be brand new.
I'm excited for the possibility that Andromeda will invoke that joy of discovery, and that sense of "wow I'm the first human to set foot here." ... I just hope we brought enough thermal clips. Just in case.