If Movie makers can weave a stunning tale of interdimensional time and distance travel to far away galaxies that spans seconds to hundreds of years in an instant out of accepted scientific theory (like the movie "Interstellar"). So too can a game maker like Bioware for Mass Effect Andromeda. It's called science fiction folks. It's make believe.
All fiction is "make believe", but all types of fiction have rules and different genres have different rules. Science fiction, being based in real-life science (whether practical or theoretical), happens to have a lot more rules. The purpose is to explore technology or scientific ideas that are not yet available or exists at a purely theoretical level (like FTL), and the effects this technology or these ideas will have on society at large.
We are supposed to suspend belief and judgment and just enjoy the darn story. The more real scientific theory they can weave into the plot the better. But some of us really need to get a grip on our access to fantasy. And stop judging and holding these things up like they are reality. We accept Superman from Krypton, the phantom zone, Green Lantern, Star Wars, Star Trek and etc for what they are and just enjoy them.
Out of the examples you mentioned, only Star Trek could be considered science fiction, but even Star Trek has been very schizophrenic about its adherence to scientific principle, sometimes doing a very good job and sometimes veering straight into the realms of fantasy (Q, anyone). And that's not even getting into its legendary, utterly nonsensical technobabble.
As for Star Wars, George Lucas has admitted that's it's science fantasy. And Green Lantern and Superman? They're science fantasy just like Star Wars, if not more heavy on the fantasy part due to the complete absence of rules around how superpowers work.
Why not Mass Effect Andromeda.
Because it breaks the precedent set by Mass Effect 1 more than ME2 or ME3 (minus the ending, which is a whole 'nother ballpark of precedent-breaking) ever did. A series of works that take place in the same universe has to run on the same principles established in the very first work, to preserve continuity. It's like developing a new game, you develop the rules for how that game is meant to be played and then every player plays the game according to those rules. The whole point of the game breaks down if you keep arbitrarily breaking the rules as you play. Basically, no one likes cheating.
The exact same principle applies to works of fiction. When writers break their own rules, they're effectively cheating, and it will make readers/watchers/players feel cheated. That's why people hate Deus Ex Machinas so much, they're effectively a Konami Code that magically solves the story's conflict, saving the writer the trouble of helping the protagonists find a legitimate way out of it. Internal consistency is the Alpha and Omega of fiction, even in very speculative fiction like fantasy where even the most impossible concepts can be possible and even commonplace (like magic).
I don't want any semblance of reality in Mass Effect Andromeda. I hope the writers and developers fill it with the most wild azzed, insane, mind bending scenarios and theories they can imagine. I don't care if people and creatures can traverse the expanse between galaxies at the unmeasurable speed of a thought. Appear in MW in a flash, then zoom-pow back to Andromeda in an instant. Just let Bioware bring it on without a ton of the strait jackets I've read in some of these opinions. And I am good to go.
Smokey, this isn't Calvinball, this is Mass Effect, there are rules!