I believe if ever there was an outside chance of a Mass Effect game hitting 10 million sales it's this holiday season because the competition is shocking this year.
Cod: ghosts 2 - will still do retarded numbers - but it's the unwanted sequel to the worst of the worst
Gears 4 - exclusive to trailing platform, second rate exclusive
Deus Ex: Mankind Divided - very niche series unfortunately, sells poorly
Watch Dogs 2 - could tank Ubisoft?
Titanfall 2 - multiplatform this time. I suspect this will be the breakout hit this year.
Also, no other big budget AAA RPG in sight. Might even be Game Of The Year at this rate. If not 10 mil it certainly it has the potential to eclipse the numbers of any previous release in the series by some margin.