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If you meant that ME:A must wow the gaming community, then I agree with you. The studio's reputation is at stake after the disastrous ME3 ending.
Mass Effect is a good IP. The question is can the studio take advantage of its potential and their own internal skills? If Bio succumbs to EA's incessant money grabbing policies this franchise may tank. A focus on exploring this big, galactic cluster is insufficient... Mako or no. All you need to do is look at Elite Dangerous . It's humongous but also sparsely populated... hardly a good combination.
So, the game must be fun to play, appeal to the romantics and RPG fans to some extent and appeal to the button smashing crowd without dumbing down the game, again. Add a pinch of something new and exciting and totally avoid major bugs at launch and we may yet see your hit.