I'm going to echo others here: No.
Also, as much as I love ME, it's really not the greatest sci-fi story ever told either, because I can cite a ton of novels in the sci-fi genre that are all superior to ME such as the entire Foundation series by Isaac Asimov, Fahrenheit 451 by Ray Bradbury, I Have No Mouth and I Must Scream by Harlan Ellison, The Peripheral by William Gibson (and I should probably throw in Neuromancer) , Snow Crash by Neal Stephenson (I'm also fond of Cryptonomicon and Seveneves), 2001: A Space Odyssey by Arthur C. Clarke (and definitely Childhood's End), The Left Hand of Darkness by Ursula K. Le Guin, the Darwin's Children novels by Greg Bear, The Sparrow by Mary Doria Russell (and the sequel called Children of God), Perdido Street Station by China Mieville, and so on.
I think the Xenogenesis trilogy by Octavia Butler was great and touches on human-alien hybrids. Try reading that instead, because trying to toss the surprise addition of human-alien hybrids into ME:A on top of exploring a new galaxy and the Remnant just doesn't work for me from a logical and scientific standpoint. The only way I think human-alien hybrids would be possible in the ME-verse is if Synthesis were canonized (in which case fundamental changes to all life might make it possible) and that events in Andromeda took place after ME3. Otherwise, nope, nuh-uh, not happening.