Genre: Cyberpunk but with (some) magic and fantastical creatures. I hesitate to call it "science fantasy" because it would be heavily focused on the sci-fi elements.
Setting: A sprawling metropolis made up of many distinct districts. I love my games to be as atmospheric as they are story rich and character driven so there would be a lot of detail to the world in order to bring it to life. Phrases like "expansive" and "open world" often turn me off. Personality and substance > size and game length.
Themes: Identity; tradition/culture vs social entropy; corruption; social and technological apathy; corporatocracy, authoritarianism, and police brutality. Heavy, sure, but humor would be mandatory--both dark and light-hearted.
Gameplay: I'm a tabletop gamer at heart so choice is important to me in RPGs. The more subtle the choices the better. No morality system, just a lot of consequences. There would also be a lot of freedom to handle things the way you want to, whether it's through diplomacy, stealth, intimidation, blackmail, violence, etc. Combat would be real time with the ability to pause and focused on strategy over pure action. It would be challenging, and particularly punishing for players who are reckless. There would be the option to lower the difficult for those who just wish to enjoy the story though.
PC and companions: Customize the player character how you want to play the game. Choose your name, gender, appearance, race, and a small amount of background information that would affect how NPCs react to you. There would be several "ability trees" but no classes. Companions would be optional if you want to go lone wolf, but they would be as well written and varied as those from Bioware's games. However, your actions affect their actions towards you. Behave so completely against their personal ideals and they may leave, confront, or betray you. Some might betray you anyway. People be people, yo.
NO: Tedious fetch quests, resource gathering, visually pleasing but empty environments, or obnoxiously elaborate crafting systems. The crafting system would probably be limited to cybernetic augmentations and some weapon enhancements.
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Yeah, I guess you could say I'm excited for Cyberpunk 2077 because it may be the closest I get to this in video game form!