Probably not, but what I consider an arsepull is in many ways a lot more liberal than most. I think most stories, in lieu of 100% dedicated concrete facts, are more concerned with connecting with the audience than they are with establishing or maintaining their rule set. In general, I place quite a bit of ME's writing in this category, the whole trilogy included.
In Bioware's case, aside from the benefit of leaving the endings behind, they might like the idea of Andromeda because it could let them maintain their favorite elements of the ME universe while connecting it to a new technology and races, which Mass Effect couldn't really do otherwise. And I suspect more than a few people are curious to see how this pans out.
That kind of revamp could turn out great, like Bryan Fuller's Hannibal or turn out sloppy, like Heroes Reborn.
Before the reveal about the story taking place in Andromeda, I'd a notion that the rest of the Milky way was going to be explored. Another thing the relays did, or rather the reliance on the relay network did, was essentially shut off any attempt to explore the rest of the galaxy. Although the network spanned the breadth of the galaxy, only a very small portion of the star systems could possibly be accessed.
Think of the network in the same way as all the different flight paths on earth. Sure they all pretty much cover the planet. But in using that network of flight paths, we fly over the vast majority of it. So if we apply that understanding to the relay network, it means we've missed out on exploring the majority of the Milky way.
I've wondered if perhaps there is, or are, other relay networks in our own galaxy. Networks that never intersect with ours or others, that are inaccessable by any other means than the network itself or millions of years of sustained ftl travel. That could mean that the reaper threat us very much still ongoing, only for a parallel galactic civilization that we have no clue about and they us.
Not the direction they chose to go, but it might have been interesting to explore more of our own galaxy only to stumble across a revelation like that.