I spent more time being misty or teary in ME than anything else in my life.
Tabarnak, I like to think of myself as being relatively masc and in frame most of the time, but every time I play ME it's like some alien device gives me the emotional stability of a twelve year old girl for the duration. I'm not complaining but sheesh.
Pretty much all of Shep and Kaidan's relationship stuff
Virmire
"I remember me"
Shep saving her old friend squadmate Toombs
Benezia and Liara
Shep going off to stop the Reapers and the ending credits of ME1
Shep's meltdown at the council for walking on her legacy in ME2
Tali's trial and after her dad dies
Legion in ME2
Garrus getting wounded
Samara's story
Thane's story
The final scene with Jack's friendship in ME2
Seeing David Archer for the first time
Suicide Mission
Leaving Earth
James' past
Pretty much the entire emotional state of 3
Tuchanka
Mordin's sacrifice
Rannoch
Mesanna-Distress Signal
Citadel Party
Thessia
The Elcor Ambassador trying to save his people in ME3
Shep's realization she was being used the entire time in 2 during Cronos
The Battle for Earth
the fact it all had to end...
And his list was just off the top of my head too. =x