Yeah, I want to say Dragon Age, because I came into Bioware gaming through DA: Origins, and I dearly love my Grey Warden and Leliana, but ultimately, that's the problem with DA. With ME, you get to stick with the same character (and characters in the case of Liara, Garrus, and Tali) while the story gets bigger, as opposed to the story getting bigger in DA, but always having to adjust to a new character, new locations, and a new set of squad mates each time. ME feels like a long TV series, with all the detail that entails, while DA feels more like a movie and two sequels that don't quite resemble each other. I like that in ME you can romance Liara all the way through (albeit, only in Lair of Shadow Broker in ME 2, but her picture is always on that desk). I like that Shepard becomes more nuanced over the games, that she (in my case) becomes such a well rounded person. And I love that characters like Garrus and Tali have story arcs that build throughout the series. It's not the same for the support characters in DA.
And while I've replayed DA a couple of times, I'm discovering that it's far more fun to replay ME 2 and ME 3 (I'd replay ME 1 more except that I really detest the missions with the vehicle, trying to climb over mountains, etc. It bores me. Plus, with Genesis, I can switch around origins/careers/decisions easier than swapping around worlds in the Dragon Age Keep.) I also prefer playing as a warrior/rogue as opposed to a mage and DA seems really geared for mages, while ME seems more geared for the Soldier which is the career I prefer most. Also, if I replay DA II, it's for the sake of revisiting sarcastic Hawk, not because I want to relive the story of how Kirkwall fit into the time period after the Fifth Blight or how the mage/templar tensions led to a war that really didn't go anywhere in DA: Inquisition. In ME 2, I can discover something new, a conversation, a way of looking at things, that resonates in ME 3.
Now, I'm not sure how I'll feel about ME:Andromeda with no more Shepard or the rest, or if they will make DA 4 (whatever it is) to flow from DA:I in a way that is more appealing to me. All I know is that as it stands now, I prefer ME over DA.
I will say that it took me much longer to get used to the game play with ME than it did for DA. Since I'm not really in it for the shooting and killing, I found the mouse and keyboard for DA:O and DA II and a controller for DA:I much easier to utilize than all the keys and mouse commands required for ME. (There are still times when my fingers slip in the middle of a fight and I'm desperately searching for my WASD keys while frantically clicking my mouse. That never happened to me with DA.)