100 réponses à ce sujet

[ZipZap2000]

You're great

*headbutt love*

[Female Commander Shepard]

*headbutt love*

Aww

[FemHawke FTW]

*headbutt love*

I like this human, they get it!

[ZipZap2000]

I like this human, they get it!

 

 

WHO ARE YOU CALLING HUMAN!

 

[Remix-General Aetius]

I'm pretty sure ME1 already beat you to butchering the lore of the original setting. Unless you think Navigator Priestly is the oldest 20 year old ever (remember his grandfather fought in the first contact war).

 

Priestly is the   LOCKDOWN    guy. PRESSLY is the one you want.

[In Exile]

Not necessarily - the exact pathophysiology (and that terminology directly implies aging is a disease, I dont care) is currently unknown, but we have a pretty good idea. Obviously, telomere shortening alone is insufficient to explain the aging phenotype. Telomere shortening and free radical production causing gradual mitochondrial DNA damage and eventual nuclear DNA damage is sufficient to explain most of the aging phenotype. Other possible causes have also been proposed, and are plausible.

Point is, immortality in the sense you are speaking of is biologically impossible. Im not talking about the poorly and unfortunately named "biological immortality" of such species as the Hydra. Aging happens because of entropy. **** breaks down with time, it is what it is, and cellular machinery goes to great extent to prevent this from happening. Indeed, current research into anti-aging is almost exclusively focused on exactly this. Additionally, we know from comparative biology that many animal species can live to be well over 150-200 years (and almost all of them exhibit a degree of metabolic suppression, further evidence for a mitochondrial role in the process) - including bowhead whales, to use a mammal as an example to counter the different physiology of other long-lived species, such as certain tortoises. And on the opposite end of the spectrum are many short-lived species, such as canines, which not only age considerably faster but also develop age-correlated diseases such as neoplasia faster (but in relative proportion to their life span, which again suggests a strong correlation between aging and nucleic acid mutation with time). Clearly, evolution can have a dramatic effect on both slowing aging and prolonging life, or on the opposite, depending on selective pressures.

So, I can quite easily foresee a (possibly relatively near) future where anti-aging treatments are used to prolong both lifespan and relative youth. But eventually, this will inevitably reach a wall. True immortality, or close enough to it, could probably only be attained through synthetic consciousness.

But who would want to live forever anyways. If someone wants immortality, I'm quite certain that they are a moron and they not only cannot comprehend the nature of "forever" and how horrifying it would be to exist eternally, but also do not appreciate their own life to the degree that they should.

 

What you're talking about in terms of anti-aging treatments is a radical, fundamental alteration at the genetic level (and I mean in terms of scale, not necessarily interference with genes). We have no idea and no concept of what we could even do or would happen if we could actually rejuvenate cells in this way. What I'm talking about is simple: if we have the means to actually repair cellular damage in this way, conceptually, we have a conceptual problem: explaining why we can't repair all cellular damage (remember, aging is an aggregate phenomenon - it's not about what happens to a cell, but what happens to cells in aggregate. 

 

Or to put it differently: **** breaks down over time, but we're talking about a process that's difficult to comprehend or conceptualize, and would likely result in functional immortality. 

[Female Commander Shepard]

WHO ARE YOU CALLING HUMAN!

You guys are what makes this forum great

[Furisco]

Step back, don't get too hyped, don't follow the game like a bloodhound online for months and months before it's released, don't start expecting particular things, and then sit back and experience it.  

 

It might be great.  It might be disappointing.  Angels may float down from heaven and sing and aria as you play the final moments.  You may fall into a pit of despair that you can't climb out of.  No one knows and there's no point speculating.

 

Just wait.  Go distract yourself and then simply play it. 

It's nice to see that people can be cool in this forum.

[Female Commander Shepard]

It's nice to see that people can be cool in this forum.

I know! It's always really nice to be able to have a calm and respectful conversation w/ someone without there being a huge argument

[Matthew Ryder]

I know! It's always really nice to be able to have a calm and respectful conversation w/ someone without there being a huge argument

I completely agree. Say, who wants to talk about the Mass Effect 3 endings? 


 

Never mind.... 

[Female Commander Shepard]

I completely agree. Say, who wants to talk about the Mass Effect 3 endings? 
 
Never mind.... 

That's exactly how it feels. I went in thinking people on here would be nice and respectful, instead I was somewhat attacked lol

[Commander Rpg]

I can't shake off these uneasy feelings about Andromeda.

Nor do I. That's why "shelf" is the winning word for me.

 

 

p.s.

 

The song is now "Greenshelves".

[Kabooooom]

What you're talking about in terms of anti-aging treatments is a radical, fundamental alteration at the genetic level (and I mean in terms of scale, not necessarily interference with genes). We have no idea and no concept of what we could even do or would happen if we could actually rejuvenate cells in this way. What I'm talking about is simple: if we have the means to actually repair cellular damage in this way, conceptually, we have a conceptual problem: explaining why we can't repair all cellular damage (remember, aging is an aggregate phenomenon - it's not about what happens to a cell, but what happens to cells in aggregate.

Or to put it differently: **** breaks down over time, but we're talking about a process that's difficult to comprehend or conceptualize, and would likely result in functional immortality.

Yes, I am talking about fundamental alteration at the genetic level. But considering that we have already accomplished this to dramatically extend lifespan in laboratory animals (granted, a mammalian genome is obviously much more complex than C. elegans, but proof of concept remains) - it is not something that is fundamentally outside the reach of science, just outside our reach today. Which has never stopped anyone from research before.

I was always interested in this. Prior to my current research career, I briefly did genetics research - although in plants, not animals. We were attempting to genetically engineer nitrogen fixation in non-legume plants. It turns out that is much more complicated than one would think, and would probably take decades to accomplish. But we understood the basics of how it worked and what had to be done. We aren't even that far yet with understanding aging, but it is conceptually similar. It's a fundamentally genetic problem at its core (most likely) and genetic problems can be addressed, absolutely.

I still maintain that this would not be equivalent to some sort of immortality technology in fixing cellular damage, as you do. I was talking more about doing what I proved evolution already has - adapting the genetics of an organism, such as with gene therapy (but realistically probably in a zygote) to fundamentally extend the lifespan of the adult organism. Nature has done it countless times, why can't we?

I think you are stuck on the correcting cellular damage thing, and think that if we had the power to do that - the tech would be nearly godlike. My point is, there is a simpler way to extend life and prolong aging. Nature has already done it, countless times.

[shodiswe]

This set of Mass Effect games could be just as good as the first ones or even better.. Or maybe they won't, but at least we can hope there is something good comming our way.

 

Personaly I rather see them try to do their best, it might result in something good. If not, what did you loose?

[ZipZap2000]

I completely agree. Say, who wants to talk about the Mass Effect 3 endings?



Never mind....

People who pick destroy smell like kittens.

Dead ones.

[CrimsonN7]

Lol, your avi really fits this subject matter too. I didn't read any of this thread so I don't know if anyone else pointed this out too.

[Female Commander Shepard]

Lol, your avi really fits this subject matter too. I didn't read any of this thread so I don't know if anyone else pointed this out too.

Haha, no you were the first one to do so lol

[Female Commander Shepard]

This set of Mass Effect games could be just as good as the first ones or even better.. Or maybe they won't, but at least we can hope there is something good comming our way.
 
Personaly I rather see them try to do their best, it might result in something good. If not, what did you loose?

I admire your optimism

[CrimsonN7]

Haha, no you were the first one to do so lol

 

I'm disappointed BSN 

[goofyomnivore]

Inquisition was fun. It had some flaws, but it was a solid game I thought. I don't think ME:A will be Witcher 3 tier (I hope it is tho), but I'd be surprised if it is worse than ME3 or Inquisition. Your second game on a new engine has to be better than your first you'd think. A lot of that time spent figuring stuff out could be used to improve existing mechanics and creating innovative new ones. Writing wise IDK. I'd be surprised if they could do worse than Priority Earth and the whole ending fiasco.

[Andrew Lucas]

OP, call a doctor, explain your condition.

[CrimsonN7]

*snip*

 

Loved the Wolf Among Us btw.   I don't know if a sequel is planned or what's happening but I'm hoping. Saw your avi and I just needed to say this.

[Onewomanarmy]

OP you shouldn't make a video game matter this much to you. I understand you're excited, a lot of people are I think but making it control you this much is very unhealthy. If it turns out to disappoint you, then you'll find another video game to play and enjoy and in the meantime play another game or occupy yourself with something you like doing

I LOVE gaming as well but life is too short to worry about small stuff like this.

[Female Commander Shepard]

OP you shouldn't make a video game matter this much to you. I understand you're excited, a lot of people are I think but making it control you this much is very unhealthy. If it turns out to disappoint you, then you'll find another video game to play and enjoy and in the meantime play another game or occupy yourself with something you like doing
I LOVE gaming as well but life is too short to worry about small stuff like this.

I guess I sounded a bit crazy and insane. I over exaggerated and I came across as obsessive and that this is the only thing I care about. It's not. I just wanted legit replies. I'm perfectly healthy lol I just like video games and I really wanted some intellectual opinions on this matter. But, I've honestly gotten most the opposite.

[Female Commander Shepard]

OP, call a doctor, explain your condition.

What's OP? It's a serious question I honestly don't know