Personally I'm quite excited at the prospect of exploring the frontier of new galaxy! Especially our sister galaxy, Andromeda has always been a fascination of mine.
Sure I will be left wondering what the other races are doing and I have no idea how they are going to work our choices from the ME trilogy into the new game. Likely skirting over it abit, but I'm surprisingly alright with that. I can head canon stuff if they leave enough blank spaces. Plus, i'm one of those people that is content with the end of sheps story. I'm not upset that I wont be playing that character again and would be happy not to see him make a re-appearnce.
I like a story being wrapped up and not dragged out for the sake of it.
I do hope that it's not too similar to DA:I, it was a good enough game but and I know there are people who will disagree with this, but I felt DA:I was alittle bit soulless. It was trying to be too many things to too many people, to such and extent that it came across abit sterile. Please don't take this as a denouncement. It's just a personal opinion based on my own experience of the game. I have no doubt that other people saw it differently.
At the very least the new setting gives the developers the chance to don their visors of creativity and do something new and invigorating without being held back by previous design choices, particularly in regards to the story and world state post trilogy.
That can only be a good thing.