So what I am taking from this.
We are going to Andromeda (duh) and are opposed by a race. Is this going to be like the Prothean "race"? Not specifically one race, but the entire galactic community that call themselves the same thing.
Choices are obvious (BioWares thing) so I'm thinking we are going to have to try and win over some of these indigenous races. Prove to them that we are... I don't know. Invaders? But essentially, prove to them that we are willing to cooperate, and just want a place to call home.
The fact that they are calling it a new home means to say, we will likely never see the Milky Way again. It's not "a place to stay for the evening". It's "home". Home implies, we're not going to leave it.
And Humanity. Humans. I think that, if it wasn't already confirmed Krogans were in the game, the Ark would be human only. So, perhaps the other races onboard this venture will try to find their own homes as well. Of course, no one planet is going to be perfect for every one race. Humans are going to be better suited to one world, whereas Krogan another.